Oxidative damage mechanisms

In addition to oxidation itself, gas diffusion into the base metal can be more damaging than the actual loss of metal from the surface. Thus the loss in mechanical properties owing to diffusion of oxygen into niobium makes it more difficult to protect niobium against oxidation damage than molybdenum, even though molybdenum has less resistance to normal oxidation effects than niobium. 

As a species that has evolved in such an aggressive environment we have developed mechanisms that both defend against oxidative damage and can undertake damage repair. Free radical generation in vivo has even been adopted as a mechanism to protect against physical, chemical and biological injury. 

Comprehensive reviews published by Snodderly and Beatty et al. " explore the evidence for a protective fnnction by the macular pigment against age-related macnlar diseases and the mechanisms by which it might act. The antioxidant properties of Intein and zeaxanthin recently reviewed by Young and Lowe may rednce the degree to which oxidative damage promotes these diseases. Otherwise, becanse these... 

Sadrzadeh, S.M.H. and Eaton, J.W. (1992). Hemt obin-induced oxidant damage to the central nervous system. In Free Radical Mechanisms of Tissue Injury (eds. M.T. Moslen and C.V. Smith) pp. 24—32. CRC Press, Boca Baton. 

In recent years considerable attention has focused on the mechanisms of oxidative damage to the cornea. In a study to determine the interaction of ascorbate, hydrogen peroxide and oxygen in the eye, Riley et al. (1986) found that ascorbate promoted corneal swelling when isolated corneas were perfused with glucose-deficient medium. This was due to the rapid oxidation of... 

The risk of developing colonic cancer is raised in UC, particularly in those with long-standing extensive disease (Lennard-Jones et al., 1990). The mechanism of this increased susceptibility is unknown, although it is tempting to speculate that it is related to inflammation and resulting oxidative damage to DNA. As yet there is little evidence to support this contention. Markowitz et al. (1988) have reported a decrease in constituent and oxidant-induced adenosine diphosphate ribosyl... 

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