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Ovarian cancer cytotoxicity assay

It was carried out according to Schwikkard et al. [9] and Actinomycin D was used as a positive control [ 16]. Cytotoxicity was determined against A2780 human ovarian cancer cells, using a microtiter plate assay. The plates were seeded with cells and... [Pg.84]

Gay M, Montana AM, Moreno V, Prieto M-J, Perez JM, Alonso C (2006) Studies of interaction of trichloro r 2-cis-N, N-dimethyl-l-[6-(N , N -dimethyl-ammoniummethyl)-cyclohex-3-ene-l-yl]-methylammonium platinum(II) chloride with DNA effects on secondary and tertiary structures of DNA. Cytotoxic assays on human ovarian cancer cell lines, resistant and non-resistant to cisplatin. Bioorg Med Chem 14 1565-1572... [Pg.54]

Cytotoxicity. JM216 was evaluated in vitro using the sulforhodamine B (SRB) assay against a panel of human ovarian carcinoma cell lines, established to be representative of the range of clinical responsiveness to platinum-based chemotherapy observed in patients presenting with advanced ovarian cancer (see below) [30]. JM216 showed a similar in vitro potency to that of cisplatin itself mean /C50 values across the ovarian cell line pan-... [Pg.508]

A number of benzophenones have been assayed for their cytotoxicity towards ovarian [78,93], leukemia [14,82], and CNS [102] cancer cell lines. In addition, the guttiferones (132 and 135-142) have displayed potent cytotoxicity toward leukemia [82] and ovarian cancer cell lines [37,93],... [Pg.764]

Using a short-term ATP bioluminescence assay Boike et al. (1990) studied the ability of two me-thylxanthines (caffeine and pentoxifylline) and an inhibitor of ADP-ribosyltransferase (3-aminobenz-amide) to enhance cisplatin cytotoxicity in gynaecological cancer cell lines. Pentoxifylline enhanced cisplatin cytotoxicity in both the human cervical cancer cell line ME-180 and the human ovarian cancer cell line CAOV-3. Increasing concentrations of pentoxifylline, while relatively nontoxic to both cell lines, produced a concentration-dependent enhancement of cisplatin cytotoxicity. [Pg.748]

P-D-glucopyranosylstigmasta-5,25 diene were evaluated in the yeast based assay (Table 6.3), but none of them showed activity while the new diterpene ajugalaevigatic acid showed only a weak A2780 ovarian cytotoxic activity [11] among against a panel of cancer cell line tested. [Pg.74]

In the derivatives of 2-phenylpyridine platinum compounds 9.15, as shown in Eq. (9.5), cytotoxicity was also studied in three human cancer cell lines derived from ovarian carcinoma (CHI), lung carcinoma (A549), and colon carcinoma (SW480) by means of an MTT assay (MTT=3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) [74]. This study needs to be pursued further in future, however, in order to be able to find the role of different phosphine ligands in this field. [Pg.188]

See other pages where Ovarian cancer cytotoxicity assay is mentioned: [Pg.84]    [Pg.83]    [Pg.84]    [Pg.83]    [Pg.144]    [Pg.478]    [Pg.304]    [Pg.90]    [Pg.530]    [Pg.87]    [Pg.456]    [Pg.81]    [Pg.262]    [Pg.188]    [Pg.234]    [Pg.43]    [Pg.75]    [Pg.77]    [Pg.83]    [Pg.744]    [Pg.744]    [Pg.76]   
See also in sourсe #XX -- [ Pg.79 , Pg.80 ]

See also in sourсe #XX -- [ Pg.79 , Pg.80 ]



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Ovarian cancer

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