Other therapeutic agents

Furosemide is a diuretic agent used to treat edema in both human and veterinary medicine and requires a 48-h withdrawal period for milk produced by cattle 

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Note The three reagents should be applied as quickly as possible after each other. In combination with the Ry value, and with UV detection before application of the reagent sequence this procedure allows the identification of therapeutic quantities of thiazide diuretics and methyldopa in urine together with a series of other therapeutic agents. Mobile phase residues e. g. acetic acid, should be completely removed from the chromatograms before application of the reagent sequence. 

Drugs with thyroid hormone activity, alone or with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. 

The potential for the use of the compound in combination with other therapeutic agents should be considered and discussed. A well-known interaction is that of the reduction in efficacy of oral contraceptives when antibiotics are also taken (3). 

The extraction and purification of proteins from organisms or biological tissue can be a laborious and expensive process, and often represents the principal reason why vaccines and other therapeutic agents reach costs that become unattainable for many. Downstream processing also can be a major obstacle with respect to cost for large-scale protein manufacturing in plants. However, purification from plant tissues, while still costly, is in general less expensive than purification from their mammalian and bacterial counterparts. Indeed, some plant-derived biopharmaceuticals, such as topically applied monoclonal antibodies, may require only partial purification and thus be even less intensive in terms of labor and cost. 

It is a skeletal muscle relaxant, oxazolidinone derivative used in conjunction with other therapeutic agents to treat and discomfort associated with acute mus-... 

Disulfiram is rapidly and completely absorbed from the gastrointestinal tract however, a period of 12 hours is required for its full action. Its elimination rate is slow, so that its action may persist for several days after the last dose. The drug inhibits the metabolism of many other therapeutic agents, including phenytoin, oral anticoagulants, and isoniazid. It... 

Q9 Are there any other therapeutic agents which could help Carmen s breathing ... 

Sulphonamides, amongst the first successful chemotherapeutic agents, now have their place in medicine mainly in combination with trimethoprim. Because of the risks of adverse drug reactions associated with their use, this is generally restricted to specific indications where other therapeutic agents have clearly inferior efficacy. Many sulphonamide compounds have been withdrawn from the market. Their individual names are standardised in the UK to begin with sulfa-. ... 

The Hi antagonists display a variety of. significant drug interactions when coadministered with other therapeutic agents. For example. MAO inhibitors prolong and intensify the anticholinergic actions of the antihistamines. - " ... 

The biochemical response of patients with Paget s disease to other therapeutic agents is similar to that detailed for calcitonin except for the occurrence of the escape phenomenon, which has been observed only with calcitonin therapy. During mithramycin therapy, serum alkaline phosphatase declines more rapidly than during calcitonin therapy (L7)... 

Hyperphosphatasemia in patients with breast carcinoma usually denotes the presence of hepatic or skeletal metastases (C32, C35, Gl). Nathanson and Fishman (Nl) claimed that, in at least some patients with breast carcinoma, hyperphosphatasemia was due to the ectopic production of alkaline phosphatase by the tumor. Measurements of serum alkaline phosphatase values are of little use in monitoring the effects of endocrine ablation and other therapeutic agents (D14, Gl). 

DELFIA has been used for the detection of a wide variety of analytes, including proteins, peptides, antibodies, microorganisms, oligonucleotides (ODNs), and other therapeutic agents in different matrices, such as plasma, serum, urine, and feces [9 14]. Numerous examples have shown that DELFIA assays can offer enhanced... 

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