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Product development public-private partnerships (p-PPPs) are collaborative organizations between non-profit and for-profit organizations. They are institutionalized with public intervention and/or funding because markets are perceived as unable to adequately connect relevant resources and capabilities between science and industry in basic research. Clearly, diseases such as malaria, tuberculosis, and others that are even less well known are rampant in developing countries but are far less of a threat in most developed countries (Wheeler and Berkley 2001 Kaplan and Laing 2004). There is, therefore, little or no economic incentive to develop pharmaceutical products for these diseases (Biel 2001 Milne, Kaitin, and Ronchi 2004 Kaplan and Laing 2004). The industry s lack of enthusiasm is also a result of distribution challenges in countries with poor infrastructures and lack of awareness about these diseases in more developed countries, liability considerations, inadequate science base, and underestimation of the disease burden. Product PPPs have been developed to address... [Pg.49]

The objective of this volume of Advances in Chemical Physics is to discuss recent advances in the computational modeling of protein folding for an audience of physicists, chemists, and chemical physicists. Many of the contributors to this volume have their roots in chemical physics but have committed a significant fraction of their resources to studying biological systems. The chapters thus address the target audience but incorporate approaches from other areas because they are relevant to the methods that the various authors have developed in then-laboratories. While some of the chapters contain review sections, the principal focus is on the authors own research and recent results. [Pg.514]


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