Osteolysis titanium

Musculoskeletal In two cases of osteolysis in hips with third-generation alumina ceramic-on-ceramic couplings, periarticular tissue contained titanium wear debris (from impingement of the neck of the titanium femoral component against the rim of the titanium shell) and ceramic debris (from edge loading wear of the ceramic) [63 ]. The authors could not decide whether the titanium debris, the ceramic debris, or both had caused the osteolysis. 

Murali R, Bonar SF, Kirsh G, Walter WK, Walter WL. Osteolysis in third-generation alumina ceramic-on-ceramic hip bearings with severe impingement and titanium metallosis. J Arthroplasty 2008 23(8) 1240el3-9. 

Based on the clinical experience of UHMWPE in total hip and knee replacements, the prodnction of wear debris from artificial discs, as well as from other motionpreserving spine implants, is a clinical concern. Wear debris indnced osteolysis has been implicated as a potential mechanism for late onset pain following the faUme of stainless steel and titanium instrumented fusions [65]. Osteolysis has also been observed around certain total disc replacement designs, such as the Acroflex artificial disc [66], and case smdies of osteolysis around CHARITE disc replacements have also been reported [67-69]. According to recent conference presentations, the UHMWPE particle load around long-term implanted artificial discs may be comparable to total hip arthroplasty [70], and the periprosthetic particle concentration appears to be correlated with a local inflammatory response [71]. Although the occurrence of osteolysis with metal-on- X)lyethylene total disc replacements has thus far been relatively rare, the long-term wear behavior of artificial discs remains of clinical importance [69]. 

Kaar SG, Ragab AA, Kaye SJ, Kilic BA, Jinno T, Goldberg VM, et al. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice. J Orthop Res 2QO March 19(2) 171-8. 

Yao J, Giant TT, Lark MW, Mikecz K, Jacobs JJ, Hutchinson NI, et al. The potential role of fibroblasts in periprosthetic osteolysis fibroblast response to titanium particles. J Bone Miner Res 1995 September 10(9) 1417-27. 

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