Osteoconductive

Roessler, Wilke A, Griss PM, and Kienapfel H. Missing osteoconductive effect of a resorbable PEO/PBT copolymer in human bone defects A clinically relevant pilot study with contrary results to previous animal studies. Biomed Mater Res (Appl Biomater), 2000, 53, 167-173. 

Tabata, M., Shimoda, T., Sugihara, K., Ogomi, D., Serizawa, T. and Akashi, M. (2003) Osteoconductive and hemostatic properties of apatite formed on/in agarose gel as a bone-grafting material. Journal of Biomedical Materials Research Part B Applied Biomaterials, 67B, 680-688. 

S. Nardecchia, M. C. Serrano, M. C. Gutierrez, M. T. Portoles, M. L. Ferrer, F. del Monte, Osteoconductive performance of carbon nanotubes scaffolds homogeneously mineralized by flow through electrodeposition, Advanced functional Materials, vol. 22, pp. 4411-4420, 2012. 

Another study in Fischer rats demonstrated that MSCs do not elicit an immune response after transplantation in immunocompetent recipients. Syngeneic Fischer MSCs or allogeneic ACI MSCs were implanted via an osteoconductive matrix into the bilateral femoral gap of Fischer rats who were then sacrificed at 3, 6 and 12 weeks post-implantation (n = 4 per time point). Histological analysis showed there was no difference between the syngeneic or allogeneic implants. Allogeneic implants did not induce significant inflammatory cell infiltration or stimulate alloreactive T-cell responses [656702]. 

The results of animal tests using rats, rabbits, and dogs have demonstrated high biocompatibility and high osteoconductivity. Moreover, the most impressive bone tissue reaction of the HAp/Col composites is incorporation of the composites into the bone-remodeling process, that is, they are resorbed by osteoclastic cells. ... 

Suzuki, O. (2010) Octacalcium phosphate osteoconductivity and crystal chemistry. Acta Biomater., 6 (9), 3379—3387. 

Heimann, R.B., Schurmann, N., and Muller, R.T. (2004) In vitro and in vivo performance of Ti6A14V implants with plasma-sprayed osteoconductive hydroxylapatite-bioinert titania coat duplex systems an experimental study in sheep. J. Mater. Sci. Mater. Med., 15, 1945-1952. 

Lu, G. and Pilliar, R. (2003) Calcium phosphate sol-gel-derived thin films on porous-surfaced implants for enhanced osteoconductivity. Part I synthesis and characterization. Biomaterials, 25 (22), 5303 -5312. 

Wang, B.C., Chang, E., Yang, C.Y., Tsu, D and Tsai, C.H. (1993) Characteristics and osteoconductivity of three different plasma-sprayed hydroxyapatite coatings. Surf. Coat. Technol., 58 (2), 107—117. 

A comparative study of biological stability and osteoconductivity of hydroxyapatite coatings deposited by pulsed laser deposition (PLD) and APS was conducted... 

Nguyen, H.Q., Deporter, D.A., Pilliar, R.M., Valiquette, N., and Yakubovich, R. (2004) The effect of sol—gel-formed calcium phosphate coatings on bone ingrowth and osteoconductivity of porous-surfaced Ti alloy implants. Biomaterials, 25 (5), 865-876. 

Peraire, C., Arias, J.L., Bernal, D., Pou, J., Leon, B., Arano, A., and Roth, W. (2006) Biological stability and osteoconductivity in rabbit tibia of pulsed laser deposited hydroxyapatite coatings. J. Biomed. Mater. Res., 77 (2), 370-379. 

Inclusion of porosity, with the aim to improve the osteoconductivity, can be introduced by the addition of soluble inclusions such as sucrose, sodium hydrogen carbonate, sodium hydrogen phosphate (Takagi and Chow 2001), or calcium carbonate that reacts to evolve carbon dioxide (Walsh et al. 2001). These reactants produce ionic substitutions in the structure and further improve the resorbability. Another example is that of strontium, which has been shown to be incorporated at low concentrations, while higher concentrations require a heat treatment (Leroux and Lacout 2001b). Since the cement is designed to harden in the body, the composition is modified in situ by reaction with the physiological solutions. 

Bioresorbable p-tricalcium phosphate is occasionally used in conjunction with hydroxylapatite to improve solubility (Klein et al. 1984, Yamada et al. 1997) and hence the osteoconductivity. Applications include nose reconstruction (Abe et al. 2001), fusion of the backbone (Ueda et al. 2001), and use as a bone graft (Fujibayashi et al. 2001). 

---