Ossifying fibromyxoid tumor soft parts

Ossifying fibromyxoid tumor (OFMT) of soft parts is a slowly growing mesenchymal lesion with a propensity to arise on the extremities, in the deep subcutis or skeletal muscles. Microscopically, this neoplasm is composed of lobulated nests of compact, cytologically bland round cells in a variably myxoid or densely hyalinized stroma. An incomplete shell of lamellar bone is a usual feature, but it may be absent in selected instances. The tumor cells of OFMT stain strongly and diffusely for S-100 protein and vimentin in most cases.Occasional reactivity may also be seen for keratin, CD57, synapto-... 

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Miettinen M, Finnell V, Fetsch JF. Ossifying fibromyxoid tumor of soft parts—a clinicopathologic and immunohistochemical study of 104 cases with long-term followup and a critical review of the literature. Am J Surg Pathol. 2008 32 996-1005. 

FolpeAL, Weiss SW. Ossifying fibromyxoid tumor of soft parts A clinicopathologic study of 70 cases with emphasis on atypical and malignant variants. Am J Surg Pathol. 2003 27 421-... 

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