Osmotic balance osmoregulation

The kidney of most fish is primarily involved in hematopoiesis and osmoregulation. Fresh-water fish are hypertonic relative to the water. The continual osmotic uptake of water is balanced by production of as large amounts as 2-4 ml/kg/h of dilute urine. Salt-water fish, on the other hand, are hypotonic relative to their environment, resulting in body water loss. In response, marine species produce much smaller volumes of urine. Large differences exist among different fish species in regard to nephron structure to facilitate these functional responses. These features may influence the renal contribution to drug disposition apprecia-... 

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