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Orthogonal chemical genetics

The engineered enzyme was only able to interact with the bulky substrate that enables differentiation within the target family. In lighf of fhis fact, genetic engineering and chemistry can be brought together to [Pg.33]

Chemical genetics is a subdivision of the larger field of chemical genomics. Orthogonal chemical genetics turned into an important novel discipline in the... [Pg.169]

Figure 1.24 Orthogonal chemical genetics development of analog-sensitive kinase alleles (ASKAs). Figure 1.24 Orthogonal chemical genetics development of analog-sensitive kinase alleles (ASKAs).
The first step in chemical-genetics-based target finding is to perform cellular phenotypic screening to identify compounds that elicit a desired phenotype. An array of orthogonal secondary assays is then performed to remove nonspecific... [Pg.252]

Zhou, Z., Cironi, P., Lin, A. J., Xu, Y., Hrvatin, S., Golan, D. E., etal. (2007). Genetically encoded short peptide tags for orthogonal protein labeling by S and AcpS phosphopantetheinyl transferases. CS Chemical Biology, 2, 337—346. [Pg.118]

See other pages where Orthogonal chemical genetics is mentioned: [Pg.176]    [Pg.176]    [Pg.176]    [Pg.33]    [Pg.219]    [Pg.230]    [Pg.176]    [Pg.176]    [Pg.176]    [Pg.33]    [Pg.219]    [Pg.230]    [Pg.187]    [Pg.277]    [Pg.332]    [Pg.333]    [Pg.246]    [Pg.600]    [Pg.611]    [Pg.321]    [Pg.418]    [Pg.204]    [Pg.168]    [Pg.37]    [Pg.669]    [Pg.604]    [Pg.523]    [Pg.598]    [Pg.56]    [Pg.97]    [Pg.92]    [Pg.284]    [Pg.82]    [Pg.354]    [Pg.12]    [Pg.481]    [Pg.164]   
See also in sourсe #XX -- [ Pg.169 , Pg.176 ]



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