Opioid receptor-like receptors

ORLl receptor, acronym of orphan opioid receptor-like receptor ( nodceptin). 

Nociceptin is an opioid peptide, which is the endogenous ligand for the opioid receptor-like protein (ORL). 

Drake C, Patterson T, Simmons M, Chavkin C, Milner T. Kappa opioid receptor-like immunoreactivity in guinea pig brain ultrastructural localization in presynaptic terminals in hippocampal formation. J Comp Neurol 1996 370 377-395. 

Mollereau, C. and Mouledous, L. Tissue distribution of the opioid receptor-like (ORL1) receptor, Peptides 2000, 21, 907-917. 

Butour, J.-L., Moisand, C., Mazaruil, H., Mollereau, C., Meunier, J.-C. Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids, Eur. J. Pharmacol. 1997, 321, 97-103. 

Kawamoto, H., Ozaki, S., Itoh, Y., Miyaji, M., Arai, S., Nakashima, H., Kato, T., Ohta, H., Iwasawa, Y. Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist 1 -[(3R, 4R)-1-Cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397), J. Med. Chem. 1999, 42, 5061-5063. 

Meunier, J.-C. Nociceptin /orphanin FQ and the opioid receptor-like ORL1 receptor, Eur. J. Pharmacol. 1997, 340, 1-15. 

Opioid-receptor-like 1 (ORL1) B. Sundermann and C. Maul 467... 

Li X, Keith DE Jr, Evans CJ. Multiple opioid receptor-like genes are identified in diverse vertebrate phyla. FEBS Lett 1996 397 25-29. 

Neal CR, Jr., Mansour A, Reiiischeid R, Nodiacker HP, Civelli O, AMI H, Watson SJ, Jr. (1999) Opioid receptor-like (ORLl) receptor disdibudon in die rat central nervous system comparison of ORLl receptor mRNA expression widi T-[ Tyr]-orphauiii FQ binding. J Comp Neurol 412 563-605. 

Opioid-Receptor-Like 1 (ORLl) Receptor and Its Endogenous Ligand Orphanin FQ/Nociceptin (OPQ/N), 444... 

Jong, L., Zaveri, N., Toll, L. The design and synthesis of a novel qui-nolizidine template for potent opioid and opioid receptor-like (ORLl, NOP) receptor ligands. Bioorg. Med. Chem. Lett. 2004, 14, 181—185. 

Meunier JC, Mollereau C, Toll L, et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995 377 532-535. 

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