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Origin recognition complex

HBOl Histone acetyltransferase bound to ORCl (origin-recognition complex subunit 1). A MYST family HAT involved in DNA replication. [Pg.295]

E.-M. Ladenburger, C. Keller, and R. Knippers, Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA rephcation. Mol. Cell. Biol. 22, 1036-1048 (2002). [Pg.246]

C. Keller, E.-M. Ladenburger, M. Kremer, and R. Knippers, The origin recognition complex marks a replication origin in the human TOPI gene promoter. J. Biol. Chem. 277,31430-31440 (2002). [Pg.246]

Origin recognition complex (ORC), composed of 6 different proteins. The ORC binds in a sequence-specific manner to the origin DNA and remains constitutively bound there during the whole cell cycle. [Pg.413]

The study of replication in yeast ARSs and artificial chromosomes has revealed that initiation of replication requires not only an initiator protein but a complex of six proteins that form an origin recognition complex (ORC).493 4953 This complex, which is essential to initiation of replication, may be joined by additional proteins in a prereplication complex. At least some of the ORC proteins have their homologous counterparts in metazoa, suggesting a highly conserved initiation machinery.4953-0... [Pg.1562]

Hua XH, Newport J. Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and cdc6, but dependent on cdk2. J Cell Biol 1998 140 271-281. Maiorano D, Lutzmann M, Mechali M. MCM proteins and DNA replication. Curr. Opin. Cell Biol. 2006 18 130-136. [Pg.163]

Origin recognition complex (ORC), composed of 6 different proteins... [Pg.461]

In anaphase and during Cl, a prereplication complex (pre-RC) is formed at replication initiation sites which contains the Cdc6 protein and the MCM proteins, in addition to the constitutively bound origin recognition complex (ORC). Formation of pre-RC is negatively regulated by the C2/M cyclin -CDK complex. The Cdc6 protein and the MDM proteins are removed at the Cl-S transition due to phosphorylation by the S-phase cyclin - CDK complex which allows the onset of DNA replication. The activity of the cyclin-CDK complexes is con-... [Pg.462]

Unlike SV40 DNA, eukaryotic chromosomal DNA molecules contain multiple replication origins separated by tens to hundreds of kilobases. A sIx-subunIt protein called ORC, for origin recognition complex, binds to each origin and associates with other proteins required to load cellular hexameric helicases composed of six homologous MCM proteins. [Pg.135]

The study of replication in yeast ARSs and artificial chromosomes has revealed that initiation of replication requires not only an initiator protein but a complex of six proteins that form an origin recognition complex This complex, which is... [Pg.649]

How is replication tied to cell division Replication is tied to cell division by several proteins including the origin recognition complex, replication activator protein, and rep-hcation licensing factors. The process is controlled by cyclins, proteins produced during the Gj and S phases that bind to cyclin-dependent kinases and activate replication. [Pg.285]

In unicellular eukaryotes (kinetoplastids), two distinct PCNA are operational. Toxoplasma gondii separates an exclusively intranuclear, and a both intranuclear and a cytoplasmic PCNA in the S phase, both PCNAs serve inside the nucleus. In Plasmodium falciparum, one PCNA interacts with the original recognition complex (ORCs) of S. cerevisiae homologue, and co-localizes with it within the nucleus [1072]. The Trypanosoma brucei pre-RC protein is a Cdc45, which interacts with a... [Pg.251]

Gupta A, Mehra P, Dhar SK. Plasmodium falcipamm origin recognition complex subunit 5 functional characterization and role in DNA replication foci formation. Mol Microbiol. 2008 69 646-65. [Pg.711]

Figure 7 A qualitative network involving key interactions in the Gl-S transition of the mammalian cell cycle. Solid lines are posttranslational modifications or protein-protein interactions. Dashed arrows are transcriptional steps. Arrows mean activation, and hammerheads mean inhibition. GFs = growth factors, cdk = cyclin-dependent kinase, pRb = retinoblastoma protein, ORC = origin recognition complex. Figure 7 A qualitative network involving key interactions in the Gl-S transition of the mammalian cell cycle. Solid lines are posttranslational modifications or protein-protein interactions. Dashed arrows are transcriptional steps. Arrows mean activation, and hammerheads mean inhibition. GFs = growth factors, cdk = cyclin-dependent kinase, pRb = retinoblastoma protein, ORC = origin recognition complex.
Huang D.W., Fanti L., Pak D.T., Botchan M.R., Pimpinelli S., and KeUum R. 1998. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1 Their phosphorylation levels and associations with origin recognition complex proteins. /. Cell Biol 142 307-318. [Pg.42]

Pak D.T.S., Pflumm M., Chesnokov 1., Huang D.W., KeUum R., Marr J., Romanowski R, and Botchan M.R. 1997. Association of the origin recognition complex with heterochromatin and HPl in higher... [Pg.43]

See other pages where Origin recognition complex is mentioned: [Pg.326]    [Pg.188]    [Pg.306]    [Pg.414]    [Pg.964]    [Pg.225]    [Pg.17]    [Pg.158]    [Pg.147]    [Pg.879]    [Pg.880]    [Pg.623]    [Pg.632]    [Pg.964]    [Pg.280]    [Pg.755]    [Pg.186]    [Pg.355]    [Pg.169]    [Pg.206]    [Pg.127]   
See also in sourсe #XX -- [ Pg.413 ]

See also in sourсe #XX -- [ Pg.280 ]



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DNA replication origin recognition complex (ORC

Human origin recognition complex

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