Organotin polymer activity

Subramanian, R.V. 1984. Biologically active organotin polymers. Am. NY Acad. Sci. 446 134-148. 

Tributyltm species, especially (Bu3Sn)20 and tributyltin phosphate and naphthenate, have been used in wood preservation as fungicides and as biocides for destructive insects. Tributyltins (and to a lesser extent, triphenyltins) have been used in marine antifoulant paints due to their broad range activity. The use of organotin polymers in which the... 

The biocidal properties of most metal-containing polymers have not been studied in detail. The biological activity of organotin polymers and copolymers to various fungi and microorganisms has been found only recently. 

We have been involved in the synthesis and characterization of organotin polymers for over 30 years. The synthesis of organotin polymers was recently reviewed [2]. Much of our interest in organotin polymers is related to their antibacterial, anticancer, and antiviral activity [2-32], The antibacterial and anticancer activity of these polymers has been recently reviewed [2,3]. 

Most of these products have been incorporated into paper, plastics, textiles, and the like with only some loss in biological activity. [89] We will now move to the use of organotin polyamines as potent anticancer drugs. [74,74,96-100] Recently we synthesized a wide variety of organotin polymers derived from 4,6-diaminopyrimidines (Figure 3).[101]... 

A number of organotin polymers have been synthesized. Following is a brief review of this activity. In general the presence of organotin in polymers can be divided by its presence as an appendage in/on a polymer and its presence within the main backbone of the polymer. 

IV ANTICANCER ACTIVITY OF ORGANOTIN POLYMERS V. FUTURE WORK VI. REFERENCES... 

The use of organotin-containing compounds as potential drugs in the war against cancer has occurred since the early 1970s with some but only mild suc-cess. We more recently began to focus on the anti-cancer activity of organotin polymers that we had made for other purposes and as part of our platinum anticancer effort. Here, we will briefly review these efforts. 

Organotin epoxide monomers 30,100 104) containing fairly reactive oxirane rings and both C=C and Sn—C bonds can be used as starting components for the synthesis of new polymers, chemically active stabilizers and biocides for polymeric materials, e.g. for PVC. 

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