Anticancer Activity of Organotin Polymers

The variation in inhibition mechanism from that of cisplatin is important since it means that organotin compoimds offer an additional and different role than cis-platin in combating cancer. 

Such studies allow a better imderstanding of the possible mechanisms involved in organotin anticancer activity but also show that such mechanisms may vary with the particular cell lines as well as with the nature of the specific organotin compound. The second finding indicates that particular organotin compounds should be studied on a variety of cell lines before being cast aside as being inactive. 

Briefly, inclusion of the active ogranotin moiety as part of a polymer drug should 

Enhance activity through an increased opportunity for multiple bonding at a given site. 

Initially we screen materials for biological effects utilizing normal Balb/3T3 cells because they are easier to handle. Active compounds are then tested against cancer cell lines. 

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IV ANTICANCER ACTIVITY OF ORGANOTIN POLYMERS V. FUTURE WORK VI. REFERENCES... 

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