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Organic reactions introduction

In the post-World War II years, synthesis attained a different level of sophistication partly as a result of the confluence of five stimuli (1) the formulation of detailed electronic mechanisms for the fundamental organic reactions, (2) the introduction of conformational analysis of organic structures and transition states based on stereochemical principles, (3) the development of spectroscopic and other physical methods for structural analysis, (4) the use of chromatographic methods of analysis and separation, and (5) the discovery and application of new selective chemical reagents. As a result, the period 1945 to 1960 encompassed the synthesis of such complex molecules as vitamin A (O. Isler, 1949), cortisone (R. Woodward, R. Robinson, 1951), strychnine (R. Woodward, 1954), cedrol (G. Stork, 1955), morphine (M. Gates, 1956), reserpine (R. Woodward, 1956), penicillin V (J. Sheehan, 1957), colchicine (A. Eschenmoser, 1959), and chlorophyll (R. Woodward, 1960) (page 5). ... [Pg.3]

We should mention the recent progress in Au(I) and Au(III) catalyzed organic reactions [24, 297]. A number of groups of theoretical chemists are currently investigating the reaction mechanisms using quantum chemical methods [298-301]. Li and Mia published DFT calculations on AU5H5X hydrometal pentagons with Dsh planar pentacoordinate nonmetal centers (X = Si, Ge, P, S) [302]. The introduction of the nonmetal centers X introduces p aromaticity to MHX complexes. [Pg.211]

As mentioned in the introduction, the prototype o-QM is a highly reactive intermediates in organic reactions, including cycloaddition chemistry and DNA covalent modification, due to the high electrophilicity at the exocylic methylene carbon (see its dipolar representation in Scheme 2.11). [Pg.51]

Gilchrist, t. l. and storr, R. c. Organic Reactions and Orbital Symmetry (CUP, 2nd Edition, 1979). ghuom, r. d. Introduction to Physical Organic Chemistry (Addison-Wesley, 1970). [Pg.397]

Teaching Lab Kit (Fig. 3.5) This is a basic rotor for standard organic reactions allowing an introduction to microwave-mediated chemistry in teaching laboratories. It is designed for 16 x 20 mL glass vessels with operation limits of 1.5 bar and ca. 150 °C. [Pg.35]

The dienes and polyenes are compounds which intervene in a large number of organic reactions, as will be seen in different chapters of this book. Several excellent reviews have been devoted to theoretical studies about their reactivity, with special emphasis on the mechanism of pericyclic reactions3-5. As was mentioned in the introduction, this section will only treat, as an example, the Diels-Alder reaction, since it has been the most studied one by theoreticians. Our goal is not to cover all aspects, but instead to show the high potential and usefulness of theoretical methods in order to interpret and rationalize the experimental results. In the rest of the chapter we will concentrate on the last ab initio calculations. [Pg.18]

G Bekker The Introduction into Electronic Theory of Organic Reaction , The World", Moscow, 227, 1965, (russ.). [Pg.735]

Chapters 2 through 6 introduced many asymmetric organic reactions catalyzed by small molecules, such as C-C bond formation, reduction, and oxidation reactions. Chapter 7 provided further examples of how asymmetric reactions are used in organic synthesis. This chapter starts with a general introduction to enzyme-catalyzed asymmetric organic reactions. [Pg.451]

One important feature of ion-radical organic reactions consists of a possibility to nudge them by the introduction of active reactants. Thus, in the reaction of an electron acceptor with electron donors (nucleophiles), the addition of a tiny amount of a nucleophile, which is more active at initiation of the one-electron transfer allows the less reactive nucleophile to start its own chain propagation. A method called entrainment is widely used in chemical practice as a recent example (see Schmidt et al. 2007). [Pg.316]

With an eye toward increasing efficiency and eliminating the atom-uneconomical solvent waste stream involved in most organic reactions, a reusable, water-soluble catalyst, using bidentate phosphine 107 as a ligand, has been developed [36]. The catalyst is prepared by treatment of [RhCl(nbd)]2 (nbd=norbornadiene) with AgSbFs in acetone, followed by introduction of the phosphine ligand [37]. In the presence of 10 mol% catalyst in water/methanol (1 1) at a catalyst concentration of 2.0 mM, 108 reacted efficiently at 70°C to provide cycloadduct 109 after 12 h in 91% yield (GC analysis Tab. 13.8). Notably, the yield and rate compare favorably to results obtained with Wilkinson s catalyst... [Pg.276]

In Table 9.4.2 are shown the -values of Zn colloid at equilibrium state as a function of organic species. Introduction of oxygen gas caused disappearance of the ESR signal, which is due to the oxidation of surface Zn+ to Zn2+ the latter is ESR silent. This means that surface reaction (oxidation) takes place in the liquid phase. However, this reaction strongly depends on the kind of liquid, as seen in the figure. Moreover, we have found that there is a strong correlation between the behavior of... [Pg.537]

Introduction and overview - why study organic reaction mechanisms ... [Pg.18]

While relative acidities are extremely important to our abilities to accurately predict the mechanistic courses of organic reactions, we must recognize that in addition to acids, most heterolytic reactions involve bases as well. Furthermore, as will soon be discussed, in organic chemistry, bases generally are able to function as nucleophiles. Therefore, this chapter will serve as an introduction to the types of bases and nucleophiles that drive mechanistic organic chemistry. [Pg.45]


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Introduction and overview - why study organic reaction mechanisms

Organic Reactions An Introduction

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