Organic Reaction Studies by ESI-MS

Table 2.1 lists some of the mechanistic studies of organic and organometallic reactions reported in the literature by ESI-MS. All sorts of reactions have been successfully explored in the gas phase, such as the Baylis-Hillman reaction [211-213], C-H or N-H activation [214—219], cydopropanation reaction [220], Diels-Alder reactions [221], displacement reactions [222], electrophilic fluorination [223, 224], Fischer indole synthesis [225], Gilman reaction [226, 227], Grubbs metathesis reaction [228-231], Heck reaction [194], methylenation [232], oxidation [233, 234], Petasis olefination reaction [235], Raney Nickel-catalyzed coupling [236], ruthenium... 

Table 2.1 List of the mechanistic studies of organic and organometallic reactions by ESI-MS.

The reaction was studied by taking aliquots from the organic layer of the reaction mixture at regular time intervals until the reaction was completed. The aliquot was quenched in cold methanol and then heated to room temperature before injection into the spectrometer. Scheme 7.2 shows the reactions studied, and Table 7.1 gives the intermediates detected by ESI-MS. 

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