Mechanistic organizations

The CAMEO system is a remarkable achievement that is able to model the mechanism and course of a wide range of organic reactions with a reasonable success rate. In this sense it is also highly valuable as a tool for teaching mechanistic organic chemistiy... 

Lapworth was far ahead of his time in understanding how organic reactions occur For an account of Lapworth s contributions to mechanistic organic chemistry seethe November 1972 issue of the Journal of Chemical Educa tion pp 750-752... 

Jones, R. A. Y. Physical and Mechanistic Organic Chemistry, 2nd ed., Cambridge University Press Cambridge, 1984. 

For excellent discussions of this method see Woodward, R.B. Hoffmann, R. Ref. 1256 Jones, R.A.Y. Physical and Mechanistic Organic Chemistry, 2nd ed. Cambridge University Press Cambridge, 1984, p. 352 Klumpp, G.W. Reactivity in Organic Chemistry, Wiley NY, 1982, p. 378 Yates, K. Htickel Molecular Orbital Theory, Academic Press NY, 1978, p. 263. 

Reactions such as the Diels-Alder reaction and al-dol condensations, which are important in synthetic and mechanistic organic chemistry, are of only minor importance when drug degradation is being considered. Pharmaceutical scientists need to refocus their attention on reactions such as hydrolysis, oxidation, photolysis, racemization, and decarboxylation, the routes by which most pharmaceuticals degrade. 

D. C. Neckers, Mechanistic Organic Photochemistry, Reinhold, New York (1967), Chapter 7. 

Current interest in the electrochemical behavior of organic compounds is attested to by a number of recent books and reviews devoted to various aspects of the subject. The recent article in this series by Eberson and Schafer constitutes a good general introduction to the state of the art in synthetic and mechanistic organic electrochemistry, and also contains, in Chapter 1, many useful references for the interested reader who wishes to delve deeper into the extensive literature of organic electrochemistry. 

Clennan, E.L., Zhou, W. and Chan, J. (2002). Mechanistic organic chemistry in a microreactor. Zeolite-controlled photooxidations of organic sulfides. J. Org. Chem. 67, 9368-9378... 

Mechanistic classification system, 13 441 Mechanistic kinetic expressions, 10 85-88 Mechanistic organic chemistry, high... 

Extensive collections of pK values are available in the literature, e.g., [98-101]. It is also possible to predict pK values for a broad range of organic acids and bases using linear free energy relationships based on a systematic treatment of electronic (inductive, electrostatic, etc.) effects of substituents which modify the charge on the acidic and basic center. Quantitative treatment of these effects involves the use of the Hammett Equation which has been a real landmark in mechanistic organic chemistry. A Hammett parameter (a), defined as follows ... 

The book concludes by providing an outlook on possible future development in this field. Researchers and practitioners engaged in active work on synthetic or mechanistic organic chemistry and its practical applications will find this text to be invaluable in both its scope and its depth. ... 

This is a book which, in my opinion, should find a place in the libraries of all universities and research institutes, where people are engaged in active research in synthetic or mechanistic organic chemistry. The task taken by the author was Herculean which the author has carried out with commendable skill, when he could bring in a reasonable amount of space, all the different aspects of ion-radical chemistry. The book is characterized by the lucidity of presentation, which has made it immensely readable (Asish De, Indian J. Phys. 11 A (4), 401, 2003). 

Mechanistic Organic Photochemistry, A New Approach to (Zimmerman) Mercury Photosensitization, Isotopic Effects and the Mechanism of... 

---