Oral anticoagulants interaction

Grau E, Perella M, Pastor E. Simvastatin-oral anticoagulant interaction. Lancet 1996 347(8998) 405-6. 

Sanchez B, Muruzabal MJ, Peralta G, et al. Clarithromycin oral anticoagulants interaction report of five cases. Chn Drug luvest 1997 13 220-2. 

Grau E, Fontcuberta J, Felez J. Erythromycin-oral anticoagulants interaction. Arch Intern Med 1986 146(8) 1639. 

Sdnchez B, Muruzat l MJ, Peralta G, Santiago G, Castilla A, Aguilera JP, Aijona R Clarithromycin-oral anticoagulants interaction R ort of five cases. Clin Drug Invest (1997) 13, 220-2. 

When administered concomitantly, clarithromycin and the oral anticoagulant warfarin may interact, resulting in an enhanced anticoagulant effect and therefore increased risk of bleeding. 

Drugs that may interact with gemfibrozil include oral anticoagulants and lovastatin. 

Drugs that may interact with nalidixic acid include theophylline, caffeine, oral anticoagulants, bacteriostatic agents, probenecid, antacids (containing magnesium, aluminum, and calcium), sucralfate, iron salts, multivitamins containing zinc, didanosine, antiarrhythmic agents, and melphalan. 

Drugs that may interact with miconazole include amphotericin B, astemizole, cisapride, oral anticoagulants, phenytoin, and terfenadine. 

Minocycline (Solodyn) [Antibiotic/Tetracycline] Uses Acne Action Tetracycline, bactmostatic Dose Adults Peds >12 y. 1 mg/kg PO daily X 12wk w/ food to -1- irritation Caution [C, ] assoc w/ pseudomembranous colitis w/ renal impair Contra AU gy, women of childbearing potential Disp Tabs SE D, HA, fevCT, rash, joint pain, fatigue, dizziness Interactions t Effects OF digoxin, oral anticoagulants t risk of n hrotox W/ methoxyflurane X effects W/... 

Caution [B (D if near term), M] Contra Sulfonamide or salicylate sensitivity, porphyria, GI/GU obst avoid in hepatic impair Disp Tabs SE GI upset discolors urine dizziness, HA, photosens, oligospermia, anemias, Stevens-Johnson synd Interactions T Effects OF oral anticoagulants, oral hypoglycemics, MTX, pheny-toin, zidovudine X effects W/ antibiotics X effects OF digoxin, folic acid, Fe, procaine, proparacaine, sulfonylureas, tetracaine EMS T Effects of anticoagulants monitor EGG and BP for signs of hypovolemia and electrolyte disturbances d/t D skin urine may become yellow-orange may stain contact lenses T risk of photosensitivity Rxns OD May cause NA, drowsiness, HA, abd pain, skin Rxns, lactic acidosis, and jaundice symptomatic and supportive... 

Methylphenidate is an inhibitor of drug metabolizing enzymes of the cytochrome P450 family and several interactions with drugs like some antiepileptics, antidepressants and oral anticoagulants, have been described. 

TABLE 22.1 Drug Interactions Involving Oral Anticoagulants... 

Drug interactions Concurrent administration of ReoPro with oral anticoagulants is contraindicated. Limited experience with the concurrent use of ReoPro and low molecular weight dextran during a PTCA procedure has also shown an increased risk of a major bleeding episode. Concurrent administration of ReoPro and heparin may also increase the risk of bleeding, but ReoPro is intended for use with aspirin and heparin and has only been studied in that setting. ReoPro has... 

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