Opioids hypersensitivity

Hypersensitivity to the drug or known intolerance to other opioids or any components of the products. 

The opioids generally have a high level of safety when used in therapeutic dosages. However, there are several notable exceptions. Morphine and other opioids are contraindicated in patients with hypersensitivity reactions to the opioids. In addition, morphine should not be used in patients with acute bronchial asthma and should... 

Contraindications CNS disease that affects respirations, hypersensitivity to the preservative benzethonium chloride, physical dependence on other opioid analgesics, preexisting respiratory depression, pulmonary disease... 

Contraindications Acute hepatitis, acute opioid withdrawal, failed naloxone challenge test, hepatic failure, history of hypersensitivity to naltrexone, opioid dependence, positive urine screen for opioids... 

Contraindications Acute alcohol intoxication concurrent use of centrally acting analgesics, hypnotics, opioids, or psychotropic drugs hypersensitivity to opioids... 

In mucosal sheets from porcine ileum, the delta opioid agonist DPDPE inhibits saxitoxin-sensitive elevations in neurogenic ion transport evoked by histamine [142], tryptase-like enzymes [143], serotonin [144], kallidin [145], and type I hypersensitivity [142]. These effects of DPDPE are inhibited by naltrindole. In contrast, elevations in neurogenic ion transport occurring secondary to an immediate hypersensivity reaction in the guinea pig ileal mucosa are augmented by DPDPE, indicating that the neuromodulatory actions of opioids on active mucosal transport evoked by inflammation or anaphylaxis may depend on the species examined [146],... 

The authors pointed out that bilateral deafness after heroin relapse after prolonged abstinence had been reported in previous two cases, suggesting resensitization of a tol-erized opioid system or prolonged hypersensitization of a system in withdrawal. 

Stein C, Gramsch C, Herz A (1990) Intrinsic mechanisms of antinociception in inflammation local opioid receptors and beta-endorphin. J Neurosci 10 1292-1298 Steiner AA, Branco LGS, Cunha FQ, Ferreira SH (2001) Role of the haeme oxyge-nase/carbon monoxide pathway in mechanical nociceptor hypersensitivity. Br J Pharmacol 132 1673-1682... 

Contraindications fc>r nonsalicylate NSAID therapy are the same as those for aspirin (see Box 7-I).The formation of a gastric ulcer or erosion that may bleed profusely is a serious potential problem with NSAIDs. Consequently, the nonsalicylate NSAIDs should be avoided or used with great caution in patients with active peptic ulcer disease. NSAIDs may increase the risk of GI complications even when used in conjunction with low-dose aspirin for cardioprotection. In addition, because of potential crosssensitivity to other NSAIDs, the nonsalicylate NSAIDs should not be given to patients in whom aspirin or other NSAIDs have caused symptoms of asthma, rhinitis, urticaria, angioedema, hypotension, bronchospasm, or of symptoms of hypersensitivity reactions. Opioids, tramadol, or acetaminophen may be suitable alternatives for patients with known or suspected susceptibility. 

Opioid analgesics are contraindicated in patients with a history of hypersensitivity to narcotics, because there is a... 

Contraindications. Contraindications include hypersensitivity to opioids, head trauma or increased intracranial pressure, severe respiratory depression or compromised respiratory function, and potentially, liver or renal insufficiency (46). Whether morphine or other opioids are used depends on the severity of the contraindication, and the potential benefits must be weighed relative to the risk. Anaphylactoid reactions have been reported after morphine or codeine administered i.v., although the reactions are rare (23). Morphine... 

Brandt MR, Furness MS, Mello NK et al (2001) Antinociceptive effects of delta opioid agonists in rhesus monkeys effects on chemically induced thermal hypersensitivity. J Pharmacol Exp Ther 296 939-946... 

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