Ophiorrhiza

Saito K, Sudo H, Yamazaki M, Koseki-Nakamura M, Kitajima M, Takayama H, Aimi N. (2001) Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila. Plant Cell Rep 20 261-21. ... 

Ophiorrhiza japonica Blume 0. mungos L. Japan She Gen Cao She Gen Cao (whole plant) Resin, alkaloid, beta-sitosterol, 5 alpha-ergost-en-3 beta-ol, 5 alpha-ergost-8(-14)-en-3B-ol, tannates, hydrogen cyanide.50 For circulatory and pulmonary ailments. 

The /3-carboline-fused oxazocines 210 and 211 were isolated from the methanolic extracts of Sickingia williamsi from South America <2002CME1> and Ophiorrhiza liukiuensis from Japan <2005CPB1355>. 

All terpenoid indole alkaloids are derived from tryptophan and the iridoid terpene secologanin (Fig. 2b). Tryptophan decarboxylase, a pyridoxal-dependent enzyme, converts tryptophan to tryptamine (62, 63). The enzyme strictosidine synthase catalyzes a stereoselective Pictet-Spengler condensation between tryptamine and secologanin to yield strictosidine. Strictosidine synthase (64) has been cloned from the plants C. roseus (65), Rauwolfla serpentine (66), and, recently, Ophiorrhiza pumila (67). A crystal structure of strictosidine synthase from R. serpentina has been reported (68, 69), and the substrate specificity of the enzyme can be modulated (70). 

Yamazaki Y, Sudo H, Yamazaki M, Aimi N, Saito K. Camp- 85. tothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila cloning, characterization and differential expression in tissues and... 

Ophiorrhiza tirunelvelica A.N.Henry and Subram. Rubiaceae Herb... 

N. schlechteri (Val.) Merr. Perry Ophiorrhiza australiana Benth. 

A survey of the distribution of camptothecin and its metabolites has been published. The compounds are still obtained from the bark and seeds of C. acuminata and Nothapodytes foetida. Recent studies with hairy root cultures of C. acuminata and Ophiorrhiza pumila indicate that plant tissue culture methods of production may prove feasible in the future. ... 

Other studies have also demonstrated a remarkable difference in constituents between wild plants and callus tissue or cultured cells. For example, tissue and cell culture of Ophiorrhiza pumila L. revealed the presence of 11 anthraquinones, including two new ones not present in the parent plant [338], New compounds of anthraquinone type were also isolated from Isoplexis isabelliana (Webb) Masf, Fusarium oxyspornm L. and Cruciata glabra (L.) Ehrend cell suspension cultures [339-341],... 

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