Open epicutaneous test

Sensitization. The skin irritation and sensitization potentials of 9.0% thioglycolic acid were evaluated usiag the open epicutaneous test. Reactions were not observed dutiag the challenge phase. ThioglycoHc acid was an irritant, but not a sensitizer (20). 

Feature of test Draize Open Epicutaneous Tests (OET) Beuher Assay Freund s Complete Adjuvant Test (FCA) Optimization Test Split Adjuvant Guinea Pig Maximization (GPMT)... 

These methods can be adopted to define dose relationships - as was the intent of the open epicutaneous test (OET). The availability of the threshold for induction (TIC) and elicitation (TEC) provides a valuable tool in clinical risk assessment. 

Klecak G (1983) Identification of contact allergens Predictive tests in animals. In Marzulli FN, Maibach HI (eds) Der-matotoxicology. Hemisphere, New York, pp 193-236 Klecak G (1985) The Freund s Complete Adjuvant Test and the Open Epicutaneous Test. A complementary test procedure for realistic assessment of allergenic potential. Curr Probl Dermatol 14 152-171... 

Freund s complete adjuvant test Maximization test Open epicutaneous test... 

Upon epicutaneous testing with the Belgian standard series, the (meth)acrylate series (chemotechnique), and the patient s own material, the patient reacted (after 2 days and 4 days, respectively) to epoxy resin (++,++), ethyleneglycoldimethacrylate (EGDMA) (-h-l-, +), and 2,2-bis(4-[2-hydroxy-3-methacryloxypropoxy]-phenyl)-propane (bis-GMA epoxy acrylate) (+-I-, -I-). He also reacted to the Saatigraf emulsion tested as is in a semi-open test (-H-, ++). 

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