Oligosaccharides polymerization

Li Q, Du Y-Z et al (2010) Synthesis of Lamivudine stearate and antiviral activity of stearic acid-g-chitosan oligosaccharide polymeric micelles delivery system. Eur J Pharm Sci 41 498-507... 

The important advantage of the immunosorbents based on WPG-PA is the fast rate of biospecific interaction between the oligosaccharides and antibodies. For B-trisaccharide-WPG-PA the average sorption time of monoclonal B8 antibodies was 20 times shorter than with B-trisaccharide-Sepharose 4B. The role of the flexible polymeric spacer, therefore, is in this case very pronounced. 

Xylans as true homopolymers occur in seaweeds of the Palmariales and Nemaliales, however, their backbone consists of Xylp residues linked by -(1 3) (Type X3, Fig. la) or mixed -(1 3, 1 -> 4)-glycosidic linkages (Type Xmy Fig. lb). They are assumed mainly to have a structural function in the cell-wall architecture, but a reserve function cannot be ruled out [4]. From the microfibrils of green algae (Siphonales) such as Caulerpa and Bryop-sis sp., X3 was isolated and the structure confirmed by methylation analysis, C-NMR spectroscopy [7], as well as by mass spectrometry of enzymically released linear oligosaccharides up to a degree of polymerization (DP) of... 

It has long been recognized that polymeric supports for oligosaccharide synthesis do not need to be insoluble.33 Wang et al. applied the sulfoxide glycosylation method to the synthesis of disaccharide 79 (Scheme 3.14). The key feature of this work was the base-labile linker. Sulfoxide 74 was used to glycosylate polyethylene glycol... 

Oligosaccharide syntheses employing enzymatic reactions would in principle greatly benefit from being performed on a polymer support since the support might effectively facilitate isolation of the final product. Presumably, a water-soluble polymeric support will be preferable to any insoluble support since reaction rates could otherwise become too slow. Glycosidases as synthetic enzymes would be the best candidates to study this type of the enzymic approach to oligosaccharide synthesis. 

This book covers all of the most recent (at the time of writing) developments in the field of solid support oligosaccharide synthesis. Included are chapters discussing different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports and on-resin analytical methods. Special topics such as the formation of [3-glycosidic linkages on solid support are also discussed. 

Thiem,and Klafike, W. Synthesis of Deoxy Oligosaccharides. 154, 285-332 (1990). Timpe, H.-J. Photoinduced Electron Transfer Polymerization. 156, 167-198 (1990). 

N-Linked oligosaccharides, Degree of polymerization of neutral oligosaccharides, Degree of methylation and acetylation of pectin, High mannose oligosaccharides ... 

In this paper, it has been shown that glucansucrases with different synthetic specificities can synthesize glucans with different structures and can synthesize oligosaccharides with different structures by acceptor reactions. The mechanisms by which these enzymes carry out the polymerization and by which the acceptor reactions occur has been discussed. The products resulting from the... 

Amylase, the most important endoglyco-sidase in the pancreas, catalyzes the hydrolysis of al 4 bonds in the polymeric carbohydrates starch and glycogen. This releases maltose, maltotriose, and a mixture of other oligosaccharides. 

---