Oligosaccharides glycosidation methods

I. General Introduction Glycosidation Methods for Oligosaccharide Synthesis. .. 178... 

In addition, the CB glycoside method has been successfully applied to the synthesis of some important oligosaccharides, trisaccharide 89, tetrasaccharide 98, and octaarabinofbranoside 112 as the latent-active glycosylation method, which is a valuable strategy for the rapid assembly of oligosaccharides. 

Notes and discussion. The power of modern glycosidation methods was demonstrated by combining an orthogonal (F versus SePh) and a reactivity tuning (see Chapter 6) approach. In a one-pot, four step reaction, a pentasaccharide was formed in 8% yield from donor 31 [20]. Further applications in efficient oligosaccharide synthesis have also been reported [20, 21, 23-25]. 

A review containing 32 references has been published on sequencing methods applicable in the structural analysis of oligosaccharides. A further review by Whitesides and coworkers has dealt with the enzymic in vitro synthesis of mono-, oligo- and poly-saccharides, and the effects of several parameters on the yields and selectivities of glycosidase-catalysed formation of oligosaccharide glycosides have been discussed. ... 

Note. This prefix does not include the oxygen of the glycosidic group. This is the appropriate method for naming natural products if the trivial name includes the OH group. The system is also used to name oligosaccharides (see 2-Carb-37). 

There are two established methods in use for citing locants either in parentheses between the glycosyl and glycose terms, or in front of the glycosyl prefix, as in the names of glycosides. The former (preferred) method is derived from that used to designate residues in oligosaccharides (see 2-Carb-37 and -38). 

Of the many methods described for glycoside synthesis, those predominantly used in current oligosaccharide synthesis, in which the glycosyl donor has O- or N- functionality at C-2 (that is, excluding 2-deoxyglycosides), are the following ... 

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