Glycosidation methods, oligosaccharide synthesis

The next ten chapters should provide the reader with state-of-the-art methods in glycoside and oligosaccharide synthesis from leading researchers in the field. 

R. Madsen and B. Fraser-Reid, n-Pentenyl glycosides in oligosaccharide synthesis, Modem Methods in Carbohydrate Synthesis (S. H. Khan and R. A. O Neill, eds.), Harwood Academic Publishers, Amsterdam, 1996, Chap. 7. 

Although the methodology introduced by Sinay and advanced by Chenault does essentially work, glycoside synthesis using such vinyl ethers has no definite advantage over methods such as the trichloroacetimidate or n-pentenyl approaches detailed above and suffers from relatively non-trivial procedures required in the preparation of the donor species. However, a useful application of vinyl glycosides in oligosaccharide synthesis has subsequently been developed and applied successfully by Boons. 

I. General Introduction Glycosidation Methods for Oligosaccharide Synthesis. .. 178... 

Of the many methods described for glycoside synthesis, those predominantly used in current oligosaccharide synthesis, in which the glycosyl donor has O- or N- functionality at C-2 (that is, excluding 2-deoxyglycosides), are the following ... 

This book covers all of the most recent (at the time of writing) developments in the field of solid support oligosaccharide synthesis. Included are chapters discussing different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports and on-resin analytical methods. Special topics such as the formation of [3-glycosidic linkages on solid support are also discussed. 

R. R. Schmidt, New methods for the synthesis of glycosides and oligosaccharides. Are there alternatives to the Koenigs-Knorr method Angew. Chem. lnt. Ed. Engl. 25 212 (1986). 

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