Oligosaccharide synthesis cyclodextrin

Cyclodextrins (CDs) have the ability to include the hydrophobic area of a compound, and the formed complex becomes soluble in water due to hydroxyl groups orientated on the surface of CDs. Thus, it was proposed that CDs would have similar properties as surfactants in enzymatic glycosylations. Nishimura etuL studied the utility of simple CDs for the synthesis of neoglycolipids using glycosyltransferase. In this approach, the authors attempted to use cell-media synthesis, which was named cellular-chemoenzymatic synthesis, as a triple-factor combination method, to construct oligosaccharide easily. Three types of CD, a-CD, /3-CD, and... 

Nakano, H., and Kitahata, S. 2005. Application of cyclodextrin glucanotransferases to the synthesis of oligosaccharides and glycosides. In Handbook of Industrial Biocatalysis, ed. C.T. Hon. Boca Raton, FL CRC Press, Taylor Francis Group, pp. 22-1-15. 

Cyclodextrins which are cyclic oligosaccharides built up of six, seven or eight 1-4-linked glucopyranose units (a-CD, P-CD and y-CD, respectively) may be modified by lipophilic substitution on one of their two hydrophilic faces surrounding a hydrophobic cavity to form amphiphilic molecules. A schematic model of a modified p-CD with 7 grafted C12 chains at the primary face and with 14 hydroxilic groups at the secondary face is illustrated in Fig. 2. The synthesis route of such a molecule starting from per-(6-amino-6-deoxy) -cyclodextrin is depicted in Fig. 3. 

As previously, this Chapter deals with specific tri- and higher oligosaccharides most references relate to their synthesis by specific chemical and, increasingly, en2ymic or combined methods. Chemical features of the cyclodextrins are noted separately. 

As in previous volumes, this Chapter deals with specific tri- and higher oligosaccharides most, but not all papers cited relate to their synthesis by chemical methods. It does not cover compounds made by oligomerisation of monosaccharide derivatives but, for the first time, a separate section on cyclodextrins is included which deals mainly with their chemical syntheses and modifications. Their use, for example as catalysts, and other aspects are not covered. 

As before, this Chapter deals with specific tri- and higher oligosaccharides most references relate to their syntheses by specific chemical methods, it does not deal with compounds made by the oligomerization of monosaccharide derivatives, nor does it cover the cyclodextrins. The synthesis of, e.g.. pentasaccharides is dealt with under that heading, and the required preparations of constituent parts are assumed and are not covered in their respective sections. Frequently, specific derivatives of the basic compounds are involved and this fact is often not recorded in the structural formulae used. 

Oligosaccharides 31, 202s32 -, branched 14, 174s32 -, solid-phase synthesis 5, 201s31 cyclic s. Cyclodextrins Onium salts... 

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