Construction of oligosaccharide

A central theme of carbohydrate chemistry today is the construction of oligosaccharides as they are found in glycoproteins (H. Paulsen, 1990). Three closely related methods have proven to be reliable in complex syntheses, namely the halide, imidate, and thioglycoside methods. 

Despite the great deal of progress made in the chemical synthesis of oligosaccharides, there is still room for innovation and improvement over existing methods. The need for rapid and efficient construction of oligosaccharides has dramatically increased owing to the recent advances in glycobiology and related research fields [21],... 

Table 11.2-1 General cycle used with glycosyl phosphates for the construction of oligosaccharides 1-3...

The described chemical transformations are expected to (a) increase the usefulness of carbohydrates in organic synthesis, (b) enhance our ability to synthesize various useful and/or rare sugars from other readily available carbohydrates, and (c) facilitate the construction of oligosaccharide chain with stereocontrol at the glycoside bond. 

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