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Oligopeptide spacers

HPMA copolymer Adriamycin Amide bond between drug aminoribosyl and oligopeptide spacer carboxyl Galactosamine... [Pg.64]

HPMA copolymer Melphalan Amide bond between drug amine and variable oligopeptide spacer carboxyl None... [Pg.64]

Amide bond between sugar amine and oligopeptide spacer carboxyl... [Pg.288]

Umemoto, N. et al. (1989) Preparation and in vitro cytotoxicity of a methotrexate-anti-MM46 monoclonal antibody conjugate via an oligopeptide spacer, Int. J. Cancer 43, 677-654. [Pg.425]

The structure of an oligopeptide spacer can be chosen so as to correspond to the known specifidty of certain enzymes The relationship between the structure of the... [Pg.68]

An oligopeptide spacer with aromatic azo groups was used for selective release of 9-aminocamptothecin in colon. A combination of azoreductase and proteolytic activity was responsible for selective drug release in colon while the conjugate was stable in stomach and small intestine. Absorption of the drug in vivo after oral administration was also tested. ... [Pg.35]

HPMA copolymer-doxombicin may have additional unique advantages in the treatment of ovarian cancer. It is now recognized that particularly aggressive solid tumors, such as ovarian cancer, have high levels of cysteine proteases which cleave the oligopeptide spacer Gly-Phe-Leu-Gly to release the drug. Thus, inherent properties of this and other solid tumors are particularly suited to HPMA copolymer doxorubicin delivery. [46]... [Pg.110]

See other pages where Oligopeptide spacers is mentioned: [Pg.277]    [Pg.65]    [Pg.75]    [Pg.289]    [Pg.289]    [Pg.207]    [Pg.591]    [Pg.591]    [Pg.100]    [Pg.6588]    [Pg.7]    [Pg.8]    [Pg.21]    [Pg.22]    [Pg.28]    [Pg.31]    [Pg.32]    [Pg.34]    [Pg.34]    [Pg.35]    [Pg.37]    [Pg.52]    [Pg.256]   
See also in sourсe #XX -- [ Pg.260 ]



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Oligopeptide

Spacer

Spacers

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