Oligonucleotide Drugs

Single-stranded DNA can wrap itself around carbon nanotubes [54], 

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Remaut, K., Lucas, B., Braeckmans, K., Sanders, N. N., De Smedt, S. C. and Demeester, J. (2005). FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery. J. Control Release 103, 259-71. 

Lysik, M.A., and Wu-Pong, S., Innovations in oligonucleotide drug delivery, Journal of Pharmaceutical Sciences, 2003, 92, 1559-1573. 

Lysik MA, Wu-Pong S (2003) Innovations in oligonucleotide drug delivery. J Pharm Sci 92 1559-1573... 

In an oligonucleotide-drug hydrate complex, the appearance of a clathrate hydrate-like water structure prompt a molecular dynamics simulation (40). Again the results were only partially successful, prompting the statement, "The predictive value of simulation for use in analysis and interpretation of crystal hydrates remains to be established." However, recent molecular dynamics calculations have been more successful in simulating the water structure in Ae host lattice of a-cyclodextrin and P-cyclodextrin in the crystal structures of these hydrates (41.42). 

Key Words MicroRNA non-eoding RNA translational suppression cancer oneogene timior suppressor gene diagnosis antisense oligonucleotide drug diseovery... 

X-ray diffraction study of monocrystals of oligonucleotides and oligonucleotide-drug complexes 91AG(E)1254. 

Levin AA, Yu RZ, Geary RS. Basic Principles of the Pharmacokinetics Of antisense Oligonucleotide drugs. In Crooke ST, ed. Antisense Drug Technology. New York Dekker, 2007. 

S6 outlines the products for which this guidance is applicable, such as recombinant DNA proteins, vaccines, peptides, plasma derived products, endogenous proteins extracted from human tissues or oligonucleotide drugs etc., while heparin, vitamins, and cellular blood components, for example, are not covered. 

Raw material costs for production of antisense oligonucleotide drug substances have been reduced more than 97% since 1991 through process optimization, scale-up economies, and reduced raw material costs,1,60 while the manufacturing and control associated labor costs have fallen even more precipitously. Key changes have converted the process from use of costly... 

Applications of green chemistry in the manufacture of oligonucleotide drugs 01PAC175. 

W.M. David, J. Drodbelt, S.M. Kerwin and P.W. Thomas, Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionisation mass spectrometry. Anal. Chem., 2002, 74, 2029-2033. 

An important aspect in the synthesis of oligonucleotides in gram or even kilogram quantities is the limited availability of 2-deoxynucleosides. The main source of their supply is salmon milt (the sperm sac of the male). An estimated annual crop of 237 000 tons of salmon corresponds to 15 tons of ODNs in case of application of standard methods of isolation and synthesis. It is evident that increased introduction of oligonucleotide drugs into the market will prompt search for other sources and development work on synthesis of nucleosides [55]. 

Considerations regarding the effective production and use of oligonucleotide drugs include stability, delivery and pharmacokinetics. 

Sodium acetate in antisense oligonucleotides Drug inorganic counter ion determination... 

Gelatin NF-kappaB decoy oligonucleotide Drug targeting approach [67]... 

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