Inorganic drugs

Hill, D.T, Sutton, B.M., Isab, A.A., Razi, T, Sadler, P.J., Trooster, J.M. and Calls, G.H.M. (1983) Gold- 197 Mossbauer Studies of Some Gold(I) Thiolates and Their Phosphine Complexes Including Certain Antiarthritic Gold Drugs. Inorganic Chemistry, 22, 2936-2942. 

Sodium acetate in antisense oligonucleotides Drug inorganic counter ion determination... 

Nonsteroidal Antiinflammatory Drugs (NSAIDs) and COX 2 Inhibitors Oh NO It s Inorganic ... 

Ion exchangers are sometimes used on a throwaway basis also. In the laboratoiy, ion exchangers are used to produce deionized water, purify reagents, and prepare inorganic sols. In medicine, they are used as antacid, for sodium reduction, for the sustained release of drugs, in skin-care preparations, and in toxin removal. 

The term FD C color, often seen on ingredients labels, refers to food, drug, and cosmetic colors. These are organic compounds (as opposed to inorganic pigments, such as titanium dioxide) that are so intense in color that it takes only very tiny amounts to color something, and thus they can be used in concentrations so minute that they are safe for consumption. 

The biomedical uses of polyphosphazenes mentioned earlier involve chemistry that could in principle be carried out on a classical petrochemical-based polymer. However, in their bioerosion reactions, polyphosphazenes display a uniqueness that sets them apart. This uniqueness stems from the presence of the inorganic backbone, which in the presence of appropriate side groups is capable of undergoing facile hydrolysis to phosphate and ammonia. Phosphate can be metabolized, and ammonia is excreted. If the side groups released in this process are also metabolizable or excretable, the polymer can be eroded under hydrolytic conditions without the danger of a toxic response. Thus, poljnners of this tjT are candidates for use as erodible biostructural materials or sutures, or as matrices for the controlled delivery of drugs. Four examples will be given to illustrate the opportunities that exist. 

Enzyme Assay. Na , K -ATPase, and sarcoplasmic reticulum Ca - ATPase were prepared from rat hearts (22) and dog hearts (23), respectively. Bovine heart cyclic AMP phosphodiesterase was purchased from Sigma. The enzyme reaction was carried out after 5-min pretreatment with the drug, and the amount of inorganic phosphate liberated during the reaction period was determined. 

Malik, N.A., Otiko, G. and Sadler, P.J. (1980) Control of intra- and extra-cellular sulfhydryl-disulfide balances with gold phosphine drugs Phosphorus-31 nuclear magnetic resonance studies of human blood. Journal of Inorganic Biochemistry, 12, 317-322. 

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