Olfactory bulb neurogenesis

In neonatal and adult rat and mouse brain, both PK1 and PK2 are clearly expressed in the olfactory bulb. Olfactory bulb neurogenesis may depend on PK2 signaling because PK2-null mice display a marked reduction in the size of the olfactory bulb, a loss of normal olfactory bulb architecture, and an accumulation of neuronal progenitors in the rostral migratory stream. PK1 and PK2 are... 

Hack MA, Saghalelyan A, de Chevigny A, Pfeifer A, Ashery-Padan R, Lledo P-M, Gotz M (2005) Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 8 865-872. 

Brown J, Cooper-Kuhn CM, Kempermann G, Van Praag H, Winkler J, Gage FH, Kuhn HG (2003b) Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 17 2042-2046. 

Stenman J, Toresson H, Campbell K. 2003. Identification of two distinct progenitor populations in the lateral ganglionic eminence Implications for striatal and olfactory bulb neurogenesis. J Neurosci 23 167-174. 

Corotto R, Henegar J. and Maruniak J. (1994). Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse. Neuroscience 61, 739-744. 

IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol, 137, 433-58. 

Pagano SF, Impagnatiello F, Girelli M, Cova L, Grioni E, Onofri M, Cavallaro M, Etteri S, Vitello F, Giombini S, Solero CL, Parati EA (2000) Isolation and characterization of neural stem cells from the adult human olfactory bulb. Stem Cells 18 295-300 Parent JM (2003) Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist... 

The transcription factor cAMP response element-binding protein (CREB) is considered to be involved in the regulation of specific phases of adult neurogenesis in the SVZ/olfactory bulb system (Giachino et al., 2005) and in the SGZ for hippocampal neurons (Bender et al., 2001 Nakagawa et al., 2002). 

Altman J (1969) Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferadon and migradon in die anterior forebrain, widi special reference to persisdng neui ogenesis in die olfactory bulb. J Comp Neui ol 137 433 58. 

Lemasson M, Saghatelyan A, Olivo-Marin JC, Lledo PM (2005) Neonatal and adult neurogenesis provide two distinct populations of newborn neurons to the mouse olfactory bulb. J Neurosci 25 6816-6825. 

Bayer SA. 1983. 3H-Thymidine-radiographic studies of neurogenesis in the rat olfactory bulb. Exp Brain Res 50 329-340. 

Costanzo, R.M. (1984) Comparison of neurogenesis and cell replacement in the hamster olfactory systems with and without a target (olfactory bulb). Brain Res., 307, 295-301. 

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