Old Drugs

Harrison DG, Bates JN (1993) The nitrovasodilators. New ideas about old drugs. Circulation 87 1461-1467... 

Wash the area first to remove any debris and old drug. 

Dear M. Sildenafil for hypertension Old drug, new use. Drug Topics 2005 Jul 11, http //www.drugtopics.com/drugtopics/article/articleDetail.jsp id=169471... 

You can see that the New Drug displays better survival probabilities over time than Old Drug or Placebo. You can easily convert this table to a table of Kaplan-Meier failure estimates by replacing survprob = survival with survprob = failure in Program 5.7. 

Comparison of Kaplan-Meier survival estimates is often called for in clinical trial analysis. With survival analysis, you are trying to determine which treatment group displays a better time-to-event distribution than another. Part of this analysis is the production of Kaplan-Meier estimates plots that show the probability of a given event over time for each treatment group. In the following example you see that New Drug displays better survival estimates over time than either Old Drug or Placebo. ... 

CIRCLE = OLD DRUG WITH DOTTED LINE. I = J CONNECTS POINTS. symboll c = black line = 1 v = dot i = j symbol2 c = black line = 2 v = circle i = j ... 

DEFINE BAR PATTERNS WHITE = PLACEBO, GRAY = OLD DRUG,... 

Aspirin A New Look at an Old Drug. Ken Flieger, Federal Consumer Information Center of the U.S. General Services Administration, Pueblo, CO, http //www.pueblo.gsa.gov/ press/nfcpubs/aspirin.txt... 

Achiron R, Grisaru D, Golan-Porat, Lipitz S (1996) Tamoxifen and the uterus an old drug tested by new modalities. Ultrasound Obstet Gynecol 7 374-378... 

Lapse. The phase in a relapse cycle in which a person has slipped but not returned in earnest to old drug-using behavior. 

O Connor, K.A. and Roth, B.L. (2005) Finding new tricks for old drugs an efficient route for public-sector drug discovery. Nature Reviews. Drug Discovery, 4 (12), 1005-1014. 

Indeed, most of the "progress in the development of recreational drugs has been in the search for compounds that are only modest chemical variations of centuries-old drugs. The invention of entirely new mind-altering drugs (such as lysergic acid diethylamide, or LSD) has been relatively uncommon. 

Woodle MC, Storm G (1997) (eds) Long circulating liposomes old drugs, new therapeutics. Springer Verlag Berlin... 

Among the first three old drugs to be withdrawn from the market during the tenure of the CSD were benziodarone, a vasodilator launched in 1962 and withdrawn in 1964 due to reports of jaundice, pronethalol, a p-blocker introduced in 1963 and withdrawn in 1965 due to animal carcinogenicity and phenox)q)ropazine, an antidepressant introduced in 1961 and withdrawn in 1966 due to its hepatotoxicity. 

Second, FDA had to confront the fact that prior to the 1962 Amendments it had issued hundreds of old drug opinion letters for generic versions of pioneer new drugs. It, therefore, issued a statement of policy in May 1968 revoking all of those opinions. ... 

Modem drugs that are used for treating angina pectoris are described above. However, there are some very old drugs and ways for treating angina pectoris, such as using papaverine and dipyridamole, which are successfully used even today. 

The applications containing quinidine and quinine are very well known and relatively old. Drugs such as Quinidex or Quinalan are good examples of quinidine applications. Quinine can be found in drugs such as Adaquin or Biquinate. These drugs are important in the prevention and treatment of malaria. 

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