Offspring behavior

In the second study the same group evaluated the effects of prenatal cocaine exposure on child behavior in 506 African-American mother-child pairs (363). The mothers were identified as cocaine users and non-users during the initial prenatal visits with urine screen confirmation. Offspring behavior was assessed 6-7 years later using caregiver reports with the Achenbach Child Behavior Checklist (CBCL). Analyses stratified by sex and prenatal alcohol exposure showed that behaviors in girls without prenatal alcohol exposure but with prenatal cocaine exposure were adverse 6.5% of the unique variance in behavior was related to prenatal cocaine... 

Sullivan EL, Nousen EK, Chamlou KA. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiol Behav. 2014 123 236-242. 

No acute oral MRL was derived for methyl parathion because data regarding the most sensitive effect that was observed after acute oral exposure are conflicting. Increased pup mortality and altered behavior occurred in offspring of rats exposed to 1 mg/kg/day methyl parathion during, but no effects on pup survival or on sensitive electrophysiological indices of neurotoxicity were seen at virtually the same dose, 0.88 mg/kg/day, in a similar developmental toxicity study. 

Birke L.A. and Sadler D. (1987). Differences in maternal behavior of rats and the sociosexual development of the offspring. Dev Psychobiol 20, 85-100. 

Mating animals that display a required trait and selecting offspring that also display the trait reveals genetic differences in behavioral responses such as cognition. Rats have been selectively bred for high or low emotionality on the basis of defecation rates and these two strains have been found to differ in their sensitivity to the stimulant/depressant effects of nicotine [49]. 

Barrett, B. and R. Howells. 1984. Legal control of standards lead in petrol. Sci. Total Environ. 33 1-13. Barrett, J. and PJ. Livesey. 1983. Lead induced alterations in maternal behavior and offspring development in the rat. Neurobehav. Toxicol. Teratol. 5 557-563. 

Rat 2000 pg/kg in diet (as Pacific blue marlin) gestation through postnatal day 16 Adverse behavioral changes in offspring 6... 

Given 0.05-15 mg/kg BW daily, chronic exposure Offspring showed behavioral effects at all doses at 15 mg/kg BW daily, reproduction was inhibited and offspring showed immunosuppression 2... 

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