Of Magnolia officinalis

Of the many types of phenolic compounds, not many have been shown to possess AChE inhibitory activity. The root and stem bark of Magnolia officinalis Rehd. Et Wils. contains the biphenolic lignans, honokiol (72) and magnolol (73). Both lignans increased ChAT activity and inhibited AChE activity in vitro, and increased hippocampal ACh release in vivo) These two compounds also appeared to have antioxidant antiinflammatory... 

Xu, Q., Yi, L. T., Pan, Y., Wang, X., Li, Y. C., et al. (2008) Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Prog Neuropsychopharmacol Biol Psychiatry 32, 715-725. 

Magnoliae, used as a stomachic, is the dried buds of Magnolia officinalis Rehd. et. Wils. or Magnolia officinalis van biloba Rehd. et. Wils. [2]. Also, the dry stem, branch, and root of M. officinalis or M. officinalis var. biloba known as Houpo , Cortex are used as a stomachic and antihistamine [2]. 

Constit. of Magnolia officinalis (Magnoliaceae). Powder. -140.0 (c, 0.31 in CHCI3). 

Magnolol 217 (Scheme 14.42), a simple antiviral BIPOL isolated from the bark of Magnolia officinalis, is readily constructed by the Negishi cross-coupling of 214 with its corresponding iodide 215, both readily obtained by DoM-transmetallation or DoM-iodination reaction, to yield 216, which, upon simple hydrolysis, affords the natural product 217 [158]. 

SuGii, Y. Constituents of the Bark of Magnolia officinalis Rhed. et Wils. and Magnolia obovata Thumb. J. Pharmac. Soc. Japan 50, 183 (1930) apud Chem. Abstr. 24, 3505 (1930). 

Magnolol Bark of Magnolia officinalis Rehd. and Wils Partial Ki=2.04 pM Moderate [98]... 

Several species of Magnolia, Magnoliaceae, such as M. officinalis Rehd. et Wils., M. obvata Thunb. 

Extracts of a mixture of honiokol 202 and magnolol 203 (the main constituents of the stem bark of Magnolia abovata thumb and Magnolia officinalis rhed, used in traditional Chinese medicine) have been separated by acid-catalyzed transformation of magnolol with dimethoxypropane into 204 (Scheme 57) <2006JME3426>. 

Magnolol is a bioactivator extracted from Magnolia officinalis with protective effects on cholinergic neurons. Magnolol restores the impaired abilities of learning and memory induced by scopolamine, and AChE, NOS, and SOD activities in mice [277]. 

Dean JR, Liu B, Price R. Extraction of magnolol from Magnolia officinalis using supercritical fluid extraction and phytosol solvent extraction. Ph5dochem Anal 1998 9 248-252. 

Miao HJ, Liu ZL, Li YH. Analysis of magnolol and honokiol in Magnolia officinalis Rehd et Wils by supercritical fluid extraction and capillary gas chromatography. Yaowu Fenxi Zazhi 1998 18 182-185. 

T Konoshima, M Kozuka, H Tokuda, H Nishino, A Iwashima, M Haruna, K Ito, M Tanabe. Studies on inhibitors of skin tumor promotion. IX. Neolignans from Magnolia officinalis. JNat Prod 5A % 6-%22, 1991. 

For severe vomiting, increase the dosages of Peony and Ginger and add Pericarpium Citri Reticulatae Chen Pi) and Cortex Magnoliae Officinalis (Hou Po). 

For malarial diseases with a heavy sensation in the limbs, loss of appetite, and a soggy pulse, subtract Ginger and Red Dates and add Rhizoma Atractylodis (CangZhu) and Cortex Magnoliae Officinalis (Hou Po). This results in Chai Ping Tang (Bupleurum Levelling Decoction). 

Also for ulcers with a combination of cold and heat, add Cortex Magnoliae Officinalis (Hou Po), Radix Panacis Ginseng (Ren Shen), Cortex Cinnamomi (Ron Gui), and Radix Scutellariae Baicalensis (Huang Qin). 

Several phenylpropanoids and lignans were isolated from Magnolia officinalis and Asiasarum heterotropoides var. mandshuricum as anti-tumor-promoters. The bark of M officinalis has been used in Chinese and Japanese folk medicine for the treatment of bronchitis and emphysema, and this crude drug is one of the important component of oriental prescriptions. 

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