Octanohwater partition coefficients

Poulin, P., Krishnan, K. (1995). An algorithm for predicting tis-sue blood partition coefficients of organic chemicals from n-octanohwater partition coefficient data. J. Toxicol. Environ. Health 46 117-29. 

Fenthion has an octanohwater partition coefficient (logic 0 W) of 4.8, which indicates that it has the potential to bioaccumulate in fish and nontarget organisms. 

Table 3.1 Relationship of Permeability Coefficients (K) and OctanohWater Partition Coefficients (Kow) for Parbens1 1...

Studies of the extent of absorption in humans, or intestinal permeability methods, can be used to determine the permeability class membership of a drug. To be classified as highly permeable, a test drug should have an extent of absorption >90% in humans. Supportive information on permeability characteristics of the drug substance should also be derived from its physical-chemical properties (e.g., octanohwater partition coefficient). 

Aqueous Solubilities, OctanohWater Partition Coefficients, and SoihWater Partition Coefficients of Selected Organic Chemicals... 

In keeping with the theme of this book, the unanticipated effects of respiratory exposures to chemical mixtures are examined here. As was seen in the previous sections, mixtures of irritants, as well as single sensitizing and corrosive chemicals, are known to produce respiratory effects in humans. The following are case studies from the literature which exemplify the respiratory toxicity of chemical mixtures. Each case is presented with a list of the chemicals involved, their octanohwater partition coefficients (/fow). the effects observed following the exposures, aud the literature reference (which immediately follows the case number). In all instances, the toxic effects observed were not predicted from considerations of the toxicities of the individual constituents and exposures were to mixtures of lipophiles and hydrophiles. 

Czerwinski, S.E., Maxwell, D.M., Lenz, D.E., 1998. A method for measuring octanohwater partition coefficients of highly toxic OP compounds. Toxicol. Methods 8, 139-149. 

Note K is the octanohwater partition coefficient, L is the rate of elimination due to permeation through capillaries, and is the diffiision coefficient of the drug in... 

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