Obese gene

Comuzzie AG, Allison DB. The search for human obesity genes. Science 1998 280(5368) 1374—1377-... 

Not all people who have obesity genes will be overweight. Conversely, some people who are overweight will not have these genes. This is because environmental factors also play a major role in causing overweight and obesity. 

Madej, T., Boguski, M. S., and Bryant, S. H. (1995). Threading analysis suggests that the obese gene product may be a helical cytokine. FEES Lett. 373, 13-18. 

Halaas, J. L., Gajiwala, K. S., Maffei, M., et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269, 543-546. 

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372 425 32. 

Much attention has been focused on the 146-residue cytokine Ieptin, a hormone produced by adipose tissue.141-144 Leptin, which is sometimes described as the antiobesity hormone, was recognized by mutations of the obese gene (OB) or of the OB receptor in... 

Leptin, a protein product of the recently identified obesity-gene (ob) appealed to cause weight loss in experimental animals. Journal Nature Medicine (1995). 

The discovery and cloning of the obesity gene (ob) in 1994 (Zhang et al. 1994) has led to an explosion of studies aimed at unraveling the molecular and cellular basis... 

Cavalli-Sforza, L., P. Menozzi and A. Piazza (1994). The History and Geography of Human Genes. Princeton, N.J. Princeton University Press. Chagnon, Y.C., L. Perusse, and C. Bouchard (1997). The human obesity gene map the 1997 update. Obesity Res. 6 76- 92. 

Also Y. Zhang, et al Positional cloning of the mouse obese gene and its homologue. Nature, ill, 425-432, 1994. 

D. L. Coleman, Obesity genes beneficial effects in heterozygous mice. Science, 203, (4381), 663-665, 1979. 

Genetic Factors in Human Obesity Genetic Factors in Mouse Obesity Obese Gene and Leptin Summary of the t hysiotogy of Adipose Tissue gulation Diabetes Gene and the Lcpiin Receptor... 

The "Obesity Genes" l ptin, Leplirs Receptor, Agouti. Tubby, and Fat... 

Considine, R. V, Considine, E- L., Williams, C., Nyce, M-, Magosin, S., Bauer, T., Rosato, E., Colbeig, J., and Caro, J. F. (1995). Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. /. C/iw. /nwst. 95,2986-2988. 

MacEiougald, O. A., Hwang, C.-S., Fan, H., and Lane, M- D. (1995). Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. PriTc. Natl- Acad. Sci. U.S.A. 92,9034-9037-... 

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