Oats, celiac disease safety

A. Summary of pivotal in vivo clinical studies testing the safety of oats in patients with celiac disease... 

Celiac disease is an immune-mediated disease, triggered in genetically susceptible individuals by ingested gluten from wheat, rye, barley, and other closely related cereal grains. The only treatment for celiac disease is a strict gluten-free diet for life. This paper presents a systematic review of the scientific literature on the safety of pure oats for individuals with celiac disease, which historically has been subject to debate. 

Janatuinen et al. (1995) were the first to evaluate the possible toxicity of oats in a large controlled study. Since then, a number of studies (Table 6.1) have assessed the safety of oats consumption by individuals diagnosed with celiac disease and dermatitis herpetiformis. Most studies were conducted on adults, with a smaller number of studies performed on children. 

Earlier published reviews on the safety of oats for patients with celiac disease were included in this evaluation (Dor and Shanahan, 2002 Kumar and Farthing, 1995 Schmitz, 1997 Thompson, 1997, 2003). Two... 

Kemppainen et al. (2007) presented additional data from their 5-year follow-up study on the safety of oats in patients with celiac disease (Janatuinen et ah, 2002). In the present study, they assessed the local cellular immunological responses using immunohistochemical biomarkers. Forty-two patients with celiac disease took part in an earlier... 

Health Canada (2007b). Celiac disease and the safety of oats. http //wwwhc-scgcca/fn-an/ securit/aUerg/cel-coe/oats cd-avoine-eng.php (accessed in Nov. 2008). 

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