Nutrigenomics

NO inhibitors HIF inhibitors Dandrolene-related agents Novel lipoproteins Liver X receptor agonists Nutrigenomics Nutraceuticals Brain metabolic enhancers... 

Cacabelos, R. (2005) Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer s disease. Aging Health, 1, 303-348. 

Muller M, Kersten S. 2003. Nutrigenomics Goals and strategies. Nat Rev Genet 4 315-322. 

Nutrigenomic hormone related to satiation Prevention of DNA damage Fenech et al. (2005)... 

Dairy foods present a unique opportunity from a nutrigenomics perspective, given the nature of mammalian milk as a complete source of nutrition which has been adapted over time to meet the needs of particular animals (German, 2009). The potential for dairy products to prevent DNA damage was reported by Fenech et ah (2005), who identified a reduced... 

Levesque, J. and Lamarche, B. (2008). The metabolic syndrome Definitions, prevalence and management. /. Nutrigenet. Nutrigenomics 1,100-108. 

Afman L. and Muller M. (2006). Nutrigenomics from molecular nutrition to prevention of disease. J. Am. Diet. Assoc. 106 569-576. 

In addition to fish oil, nutrigenomic studies have identified other possible modulators of TNF-a production and/or release in vitro. Kang et al. reported that soybean saponins suppressed the release of TNF-a by LPS-stimulated murine peritoneal macrophages.100 Horrigan et al. demonstrated that concentrations of caffeine that were relevant to human consumption consistently suppressed the production of TNF-a in human blood.101 Clearly, more studies that address the anti-inflammatory effects of food components in studies involving humans are warranted. 

As it has been discussed in this chapter, transcriptomic profiling of food crops is a hot application for RNA-Seq technologies. Nevertheless, the applicability of RNA-Seq in Food Science and Nutrition is still in its infancy and it is not fully exploited yet. In the near future, it can be anticipated that many relevant topics in Food Science will benefit from RNA-Seq techniques. For instance in Nutrigenomics studies, it can be expected that RNA-Seq studies will improve our limited understanding of the roles of nutritional compounds... 

Varma, V. Kaput, J. In Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition Ferguson, L. R., Ed. CRC Press Boca Raton, 2014. 

Mauray, A. Felgines, C. Morand, C. Mazur, A. Scalbert, A. Milenkovic, D. 2010. Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient miee. Genes Nutr. 5 343-353. 

Cacabelos R, Takeda M (2006) Pharmacogenomics, nutrigenomics and future therapeutics in Alzheimer s disease. Drugs Future 31(Suppl B) 5-146... 

Sanderson, L. M., de Groot, P. J., Hooiveld, G. J., Koppen, A., Kalkhoven, E., Muller, M., and Kersten, S. (2008). Effect of synthetic dietary triglycerides a novel research paradigm for nutrigenomics. PLoS OAE3, el681. 

Nutrigenomics is the consideration of how food and nutrition are influenced by genomics (remember again the fava beans of Chapter 2) and how particular diets can help overcome some consequences of genomic differences. We touch on this omic sporadically in this book. 

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