Nutrient-disease interactions

Dr. Meskin s major areas of research interest include (1) hepatic drug metabolism and the effects of nutritional factors on drug metabolism and clearance (2) nutrient-drug interactions (3) the role of bioactive non-nutrients (phytochemicals, herbs, botanicals, and nutritional supplements) in disease prevention and health promotion (4) fetal pharmacology and fetal, maternal, and pediatric nutrition (5) nutrition education and (6) the development of educational programs for improving science literacy and combating health fraud. 

Nutrient-Gene Interactions in Health and Disease, Nai ma Moustai d-Moussa and Carolyn D. Berdanier Micronutrients and HIV Infection, Henrik Friis Tryptophan Biochemicals and Health Implications, Herschel Sidransky... 

The first evidences related to gene, nutrient, and disease interaction are emerged from single gene mutation originated metabolic diseases like phenylketonuria. Phenylketonuria is an inborn error of metabolism resulting from a deficiency of phenylalanine hydroxylase and characterized by mental retardation and is treatable by a low phenylalanine diet [71]. 

The interactions in the intermediate-dose category may result in effects on the reproduction cycle of species, the utilization of nutrients, the production of biomass, and the susceptibility to disease,... 

Drug-drug, drug-disease, drug-food, or drug-nutrient interactions ... 

The subtitle of this book, "The Basis for the Genetotrophic Concept," reflects Williams s major interest in disorders that involve interactions between heredity (geneto) and nutrition (trophic). A genetotrophic disease is one caused by a genetic need for unusual amounts of one or more nutrients that are not found in diets which are adequate for most individuals. This broad concept includes genetic needs for an exogenous supply of a metabolite normally produced internally in adequate amounts, such as carnitine or glutamine. 

The word "genetotrophic" is rarely used so far, but it deserves new consideration in view of our increasing sophistication about genetics, nutrition and disease. It can include all degrees of nutrition-genetics interactions, from subtle to dramatic, and it seems far preferable to "nutrient dependencies," because we are all dependent on nutrients. 

Although the human genome project and subsequent efforts have sparked interest in the effects of SNPs on common diseases, the intersection of genomics and nutrition is relatively unexplored. To this end, nutritional genomics has emerged as a discipline that seeks to provide information on gene-nutrient interactions (and vice... 

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