Nurses’ Health Study vitamin

Cambridge Heart Antioxidant Study DATATOR Deprenyl and Tocopherol Antioxidative Therapy of Rarkinsonism FMC, Finnish Mobile Clinic Health Examination Survey GISSI, Gruppo Italiano Studio Soprawivenza Infarto HOPE, Heart Outcome Prevention Evaluation HPFS, Health Professional Follow-up Study NHS, Nurses Health Study PPR Primary Prevention Project SPACE, Secondary Prevention with Antioxidants of Cardiovascular disease in End-stage renal disease VEAPS, Vitamin E Atherosclerosis Prevention Study VECAT Vitamin E Cataract Age-related maculopathy Trial. 

With regard to other cancers, data from prospective studies are still limited. Dietary and supplemental intake of vitamin Bg was not associated with non-Hodgkin lymphoma or multiple myeloma in a cohort study of Finnish male smokers (Fim et al. 2006). Dietary vitamin Bg intake was not significantly associated with pancreatic cancer in a large cohort of Swedish women (Farsson et al. 2007). Finally, dietary and supplemental intake of vitamin Bg was not associated with breast (Cho et al. 2007) or ovarian cancer (Kotsopoulos et al. 2010) risk in the Nurses Health Study. 

The largest prospective dietary intake study to date is the Nurses Health Study (NHS), examining the relationship of vitamins to CVD (Manson et ai, 1992a,b, 1993 Stampfer et al., 1993). Researchers with the NHS have followed a cohort of 121,000 female nurses ages 30-55 at the beginning of the study since 1976. Biennial questionnaires elicited information about a wide variety of demographic, behavioral, and medical risk factors for CVD. In 1980 and 1984 semiquantitative food frequency questionnaires also asked for data on food intake pattern and supplemental vitamin use. 

The two largest studies, Nurse s Health Study (NHS) and Health Professional Follow-up Study (HPFS), were also examined together for the relationship of vitamin E and colon cancer but the findings do not provide consistent support of an inverse association between supplemental vitamin E and colon cancer risk (26). 

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