Nucleolus cell growth

Bose S, Basu M, Banerjee AK (2004) Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells. J Virol 78 8146-8158 Bouche G, Caizergues-Ferrer M, Bugler B, Amalric F (1984) Interrelations between the maturation of a 100 kDa nucleolar protein and pre rRNA synthesis in CHO cells. Nucleic Acids Res 12 3025-3035 Bouche G, Gas N, Prats H, Baldin V, Tauber JP, Teissie J, Amalric F (1987) Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing GO-Gl transition. Proc Natl Acad Sci U S A 84(19) 6770-6774. 

Ribosomal DNA gene transcription and ribosome assembly occur in the nucleolus, a highly specialized nuclear compartment. Quantitatively, the ribosomal gene transcription accounts for about 40% of all cellular transcription in living cells. These numbers reflect the relevance of this process for cell function and support the notion that regulation RNA Pol I transcription represents a key step in ribosome production and in determining a cell s potential for growth and proliferation (Larson et al., 1991 Nurse, 1985). 

Nucleoproteins consist of basic proteins in saltlike linkages with nucleic acids (Chapter VIII). Because nucleoproteins are probably present in all cells and vital to growth, there is tremendous biological interest in the histochemical detection of the nucleic acids. Chromosomes, sperm heads, and certain viruses consist largely of nucleoprotein. Two nucleic acid types occur in plant and animal cells deoxyribonucleic acid (DNA), typically present in the nucleus, and ribonucleic acid (RNA), typically found in the cytoplasm and in the nucleolus (see, however. Chapter VIII). Both contain phosphoric acid groups and purine and pyrimidine bases but differ in the pentose moieties. 

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