Nucleic add

Having settled on a definition of chemoinformatics, it is time for us to reflect on the distinction between chemoinformatics and bioinformatics. The objects of interest of bioinformatics are mainly genes and proteins. But genes, DNA and RNA, and proteins are chemical compounds They are objects of high interest in chemistry, Chemists have made substantial contributions to the elucidation of the structure and function of nucleic adds and proteins. The message is dear there is no clearcut distinction between bioinfonnatics and chemoinformatics I... 

A crystal is a solid with a periodic lattice of microscopic components. This arrangement of atoms is determined primarily by X-ray structure analysis. The smallest unit, called the unit cell, defines the complete crystal, including its symmetry. Characteristic crystallographic 3D structures are available in the fields of inorganic, organic, and organometallic compounds, macromolecules, such as proteins and nucleic adds. 

The PDB contains 20 254 experimentally determined 3D structures (November, 2002) of macromolecules (nucleic adds, proteins, and viruses). In addition, it contains data on complexes of proteins with small-molecule ligands. Besides information on the structure, e.g., sequence details (primary and secondary structure information, etc.), atomic coordinates, crystallization conditions, structure factors. 

Nucleoside (Section 28.1) A nucleic add constituent, consisting of a sugar residue bonded to a heterocyclic purine or pyrimidine base. 

Anabolism is the building up or biosynthesis, of complex molecules such as protein, nucleic adds and polysaccharides, from raw materials originating from intra- or extracellular sources. The biosyntheses are energy (ATP) requiring processes. 

Quinolones Rifampin Nitrofurantoins Nltrolmldazoles Inhibition of synthesis or metabolism of nucleic adds... 

Synthetic Polyelectrolytes as Models of Nucleic Adds and Esterases... 

Scholz B, Rechter S, Drach JC, Townsend LB, Bogner E (2003) Identification of the ATP-binding site in the terminase subunit pUL56 of human cytomegalovims. Nucleic Adds Res 31 1426-1433... 

Welsh, J. and McClelland, M. (1990) Fingerprinting genomes using PCR with arbitrary primers. Nucleic Adds Research 18, 7213-7218. 

Saenger, W. Principles of Nucleic Add Structure, Springer-Verlag, New York, 1984. 

Molecular biology Proteins (size, denaturation, protein-protein interactions, etc.) DNA—protein interactions Nucleic adds (flexibility)... 

Corpet, F. (1988). Multiple sequence alignment with hierarchical clustering. Nucleic Adds Res. 16, 10881-10890. 

Notredame, C., and Higgins, D. G. (1996). SAGA sequence alignment by genetic algorithm. Nucleic Adds Res. 24, 1515-1524. 

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