Peptide nucleic add

Figure 16.22. Structure of peptide nucleic adds and deoxyribonucleic acids.

Figure 2. A diagramtic ilhi ation of the structural diversity in anticoagulant hydrates and synthetic hetenxyciic agents.

J. Wang, DNA biosensors based on peptide nucleic add (PNA) recognition layers. A review. Biosens. Bioelectron. 13, 757-762 (1998). 

We describe two approaches to SNP analysis by MALDI-TOF MS, one involving the analysis of peptide nucleic add hybridisation probes [10], and the other the analysis of products of a novel, enzymatic invasive cleavage assay [11]. 

A solid state electrochemical approach based on a neutral peptide nucleic add (PNA) fixed as a monolayer on gold has been developed by Leclerc. Polymer 139 does not bind the neutral PNA probes but interacts strongly with the negatively charged complementary ODNs bound to the PNA probes. In the presence of 139, the complementary ODNs bound to neutral PNA move toward 139, thus, modifying the electronic properties of the pendant ferrocenyl units of 139 [252]. 

Chemistry of triazole-hnked analogues of nucleic acids 12YGK821. Chiral peptide nucleic adds with a substituent in the N-(2-aminoethyl) glycine backbone 13MOL287. 

M., Belgrader, P., and Girard, J. (1996) Peptide nucleic add characterization by MALDI-TOF mass spectrometry. Anal. Chem., 68 (18), 3283-3287. 

GrifRn, T.J., Tang, W., and Smith, LM. (1997) Genetic analysis by peptide nucleic add affinity MALDI-TOF mass spectrometry. Nat. Biotecknol., 15 (13), 1368-1372. 

Larsen, H.J., Bentin, T., and Nielsen, P.E., Antisense properties of peptide nucleic add, Biochim. Biophys. Acta, 1489,159,1999. 

Jagerszki, G., R.E. Gyurcsanyi, L. Holler, and E. Pretsch. 2007. Hybridization-modulated ion fluxes through peptide-nucleic-add-functionalized gold nanotubes. A new approach to quantitative label-free DNA analysis. Nano Lett. 7 1609—1612. 

Spontaneous complexation between CPEs and DNA has previously been described and has been used as the basis for many nucleotide-based sensors. A DNA sensor has been shown using peptide nucleic add (PNA), labeled with a fluoro-phore. In the presence of the polyfluorene, the PNA, which has no net charge, forms a complex with its complementary... 

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