Nucleic acids binding properties

Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties 157... 

Maes BUW (2006) Transition-Metal-Based Carbon-Carbon and Carbon-Heteroatom Bond Formation for the Synthesis and Decoration of Heterocycles. 1 155-211 Maiti M, Kumar GS (2007) Protoberberine Alkaloids Physicochemical and Nucleic Acid Binding Properties. lO. 155-210... 

Maiti and Kumar, in their contribution, review the physicochemical and nucleic acid binding properties of several isoquinoUne alkaloids (berberine, palmatine and coralyne) and their derivatives imder various environmental conditions. 

Their dihydrodiol precursors are only isolable in tiny quantities, insufficient for complete investigations of their biological and nucleic acid binding properties. 

The principles behind ultrafiltration are sometimes misunderstood. The nomenclature implies that separations are the result of physical trapping of the particles and molecules by the filter. With polycarbonate and fiberglass filters, separations are made primarily on the basis of physical size. Other filters (cellulose nitrate, polyvinylidene fluoride, and to a lesser extent cellulose acetate) trap particles that cannot pass through the pores, but also retain macromolecules by adsorption. In particular, these materials have protein and nucleic acid binding properties. Each type of membrane displays a different affinity for various molecules. For protein, the relative binding affinity is polyvinylidene fluoride > cellulose nitrate > cellulose acetate. We can expect to see many applications of the affinity membranes in the future as the various membrane surface chemistries are altered and made more specific. Some applications are described in the following pages. 

An important input for sensing applications of engineered nucleic acids has been their ability to show allosteric properties and thus perform as precision molecular switches. Allosteric ribozymes are frequently termed as aptazymes since they combine nucleic acid binding properties (aptamers) and catalytic activity like their protein enzyme counterparts. They possess an effector binding site that is distinct from the active site of the catalyst and it... 

Hirose, T., M. Sugita, and M. Sugiura cDNA structure expression and nucleic acid-binding properties of three RNA-binding proteins in tobacco Occurrence of tissue-specific alternative splicing Nucleic Acid Res. 21 (1993)3981-3987. 

S. Wang and E. T. Kool, Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs, Nucleic Acids Res., 22 (1994) 2326-2333. 

Various biological molecules, including peptides, proteins, and nucleic acids, generate vast chemical diversity that can be used as hosts in competition assays. One weU-known protocol is the fluorescent intercalator displacement assay for targeting nucleic acids binding properties of small molecules and proteins, pioneered by... 

Burres, N.S., Sazesh, S., Gunawardana, G.P., and Clement, J.J. (1989) Antitumor activity and nucleic acid binding properties of derdtin, a new acridine alkaloid isolated from a marine Dercitus species sponge. Cancer Res., 49, 5267-5274. 

Varkouhi AK, Mountrichas G, Schiffelers RM, Lammers T, Storm G, Pispas S, Hennink WE (2012) Polyplexes based on cationic polymers with strong nucleic acid binding properties. Eur J Pharm Sci 45 459 66... 

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