Nuclear pore complex role

Matunis MJ, Wu J, Blobel G (1998) SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAPl, to the nuclear pore complex. J Cell Biol 140 499-509... 

The role of the nuclear pore complex in adenovirus DNA entry. Embo J, 1997. 16(19) 5998-6007. 

Liu, J., Ben-Shahar, T, Riemer, D., Treinin, M., Spann, P, Weber, K., Fire, A. and Gmenbaum, Y. (2000) Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol. Biol. Cell 77, 3937-3947. 

Another participant in mRNP transport to the cytoplasm Is the nuclear cap-bIndIng complex, mentioned earlier as protection against exonuclease attack on the 5 end of nascent transcripts and pre-mRNAs. Electron microscopy experiments discussed below have demonstrated that the 5 end of mRNAs lead the way through the nuclear pore complex. Recent experiments in yeast indicate that the 3 poly(A) tail plays an Important role In mRNP transport, suggesting that a poly(A)-binding protein participates. Nucleoporins associated with the NPC cytoplasmic filaments In addition to FG-nucleoporins are required for mRNA export and may function to dissociate the mRNA-exporter and other mRNP proteins that accompany the mRNP through the pore. 

The nuclear lamina lies subjacent to the inner nuclear membrane (see Fig. 1 in the chapter by Berrios, this volume) it is a proteinaceous network composed of intermediate filament-like fibrils and is thought to provide structural support to the interphase nucleus. Results of previous studies suggest that the lamina binds specific loci on chromosomes and may thus play a role in organizing the genome within nuclei (Lud rus et al., 1992,1994 Baricheva et al, 19% Zhao et aL, 19% Rzepecki et al., 1997 Sharakhov et al., 1997). Other results suggest that the lamina may also be involved in DNA replication (see, e.g., Moir et al., 1994). The lamina appears to anchor nuclear pore complexes physically. 

The nuclear pore complex (NPC) undoubtedly assumes a central role in the communication between nucleus and cytoplasm. It controls both the export of... 

Greber U, Suomalainen M, Stidwill R, Boucke K, Ebersold M, Helenius A (1997) The role of the nuclear pore complex in adenovirus DNA entry. EMBO J 16 5998-6007 Hale T, Braithwaite A (1999) The adenovirus oncoprotein Ela stimulates binding of transcription factor ETE to transcriptionally activate the p53 gene. J Biol Chem 274 23777-23786 Harty JT, Tvinnereim AR, White DW (2000) CD8 + T cell effector mechanisms in resistance to infection. Annu Rev Immunol 18 275-308... 

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