Nuclear enlargement

Clawson GA, Blankenship LJ, Rhame JG, et al. 1992. Nuclear enlargement induced by hepatocarcinogens alters ploidy. Cancer Res 52 1304-1308. 

Ashby J, Kilbey B. 1981. Summary report on the performance of bacterial repair, phage induction, degranulation, and nuclear enlargement assays. Mutat Res 1 33-48. 

Characteristics are small acinar architecture, single-layer lining, straight luminal borders, amphophilic cytoplasm, nuclear enlargement and atypia, presence of prominent nucleoli, wispy or blue mucin content, dense eosinophilic secretions or "cancer" crystalloids, and presence of mucinous fibroplasia. 

Special attention is warranted in prepubertal testes where occasional spermatogonia can be normally mul-tinucleated and may show nuclear enlargement (giant gonadocytes), thus mimicking IGCNU (Table 16.20)." °... 

Kada T, Green M, Mandel M, et al. 1981. Summary report on the performance of bacterial repair, phage induction, degranulation, and nuclear enlargement assay. In deSerres FJ, Ashby J, eds. Evaluation of short-term tests for carcinogens Report of the International Collaborative Program. Prog Mutat Res 1 33-48. 

Renal tubular karyomegaly (nuclear enlargement) occurred in both sexes of mice exposed to 200,400,... 

Harris (1967) has studied changes in hen erythrocyte nuclei after virus-indueed fusion with HeLa cells. In such heterokaryons, the erythrocyte nuclei show the same sequence of events as that described by Graham et al. (1966) nuclear enlargement, dispersion of chromatin and new synthesis of RNA and DNA. Harris ascribes to this nuclear swelling a role in the regulation of transcription. 

Within the past two decades, the importance of nuclear magnetic resonance (n.m.r.) spectroscopy has enlarged tremendously. Its advantages over other methods in the structural and conformational analysis of such complex molecules as natural products, and particularly with regard to the still-increasing importance of medical investigations using n.m.r. techniques, is abundantly evident. Because destruction of the sample is avoided, different n.m.r. experiments can be performed repeatedly, and... 

Fig. 4. An apoptotic peripheral blood eosinophil observed under EM. The apoptotic cell displays the characteristic condensation of nuclear chromatin into large, electron-dense masses surrounding the central, relatively electron-lucent nuclear matrix. The swelling and breakage of plasma and perinuclear membranes and the release of the contents of granules from swollen, enlarged, electron-lucent granule containers within secretory cells are also observed. A single osmiophilic lipid body is found in the cytoplasm (x 18,500) (D6). Reproduced with permission from Dvorak, A. M., Images in clinical medicine, an apoptotic eosinophil. N. Engl. J. Med. 340, 437 (1999).

Due to the electric quadrupole interaction, the Mi = 1/2 and Mi = 3/2 components of the 7 = 3/2 state of 57Fe split up, giving rise to the quadrupole splitting. Derived from the interaction of the nuclear quadrupole moment with the electric field gradient at the iron nuclei, AEq provides information about the asymmetry of the electron density around the iron nucleus. The electric field gradient at the iron nucleus can be calculated to obtain AEq (97). Since both 6 and AEq are related to the electron density at the nucleus, basis sets with an enlarged flexibility at the core region... 

Hepatic 40 F (hepatocyte enlargement, focal sinusoidal dilation, pericentral acinar necrosis, nuclear vacuolation, portal inflammation) ... 

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