NSAIDs SSRIs

NSAIDs SSRIs, VENLAFAXINE Slight t risk of bleeding Unknown Warn patients to watch for early signs of bleeding... 

FIGURE 30-2. Pain algorithm. AED, antiepileptic drug APAP, acetaminophen NSAID, non-steroidal antiinflammatory drug SNRI, serotonin-norepinephrine reuptake inhibitor SSRI, selective serotonin reuptake inhibitor TCA, tricyclic antidepressant. 

MAOa Monoamine oxidase type A NSAID non-steroidal anti-inflammatory drug SSRI selective serotonin reuptake inhibitors... 

SSRIs, selective serotonin reuptake inhibitors TCAs, tricyclic antidepressants NSAIDs, non-steroidal anti-inflammatory drugs. 

SSRI = Selective serotonin reuptake inhibitor NSAID = Nonsteroidal anti-inflammatory drug CYP = cytochrome P-450 NAT2 = N-acetyl transferase type 2 J = Japanese C = Chinese A = African American. Poor metabolizers are not always at increased risk of ADR. 

Drugs that may affect beta blockers include aluminum salts, barbiturates, calcium salts, cholestyramine, cimetidine, colestipol, diphenhydramine, hydroxychloroquine, NSAIDs, penicillins (ampicillin), rifampin, salicylates, SSRIs, sulfinpyrazole, calcium blockers, oral contraceptives, flecainide, haloperidol, hydralazine, loop diuretics,... 

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

Drug interactions with lithium have been reviewed (569-573) another review focused on interactions in the elderly (573). A review of drug interactions with lithium considered both pharmacokinetic interactions [for example diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs)] and pharmacodynamic interactions (for example antipsychotic drugs, SSRIs) and summarized the most important ones in tabular form (569). 

NSAIDs Aspirin Clopidogrel Dipyridamole Warfarin Heparin SSRIs... 

ASA = aspirin NSAIDs = non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen, and diclofenac CNS stimulants include drugs such as pseudoephedrine, dextroamphetamine, theophylline, and caffeine MAO = monoamine oxidase CNS depressants include drugs such as benzodiazepines, barbiturates, and ethanol SSRIs = selective serotonin reuptake inhibitors, such as fluoxetine, sertraline, and paroxetine. Antidiabetic agents include drugs such as insulin, glipizide, glyburide, and metformin. 

ACE-I, indicates angiotensin-converting enzyme inhibitor SSRI, selective serotonin receptor inhibitor NSAID, non-steroidal anti-inflammatory drug OA, osteoarthritis. 

Prescriptions for two substances are counted toward the totals for each substance. APAP = acetaminophen SSRI = selective serotonin reuptake inhibitor SNRI = serotonin and noradrenaline re-uptake inhibtor HCTZ = hydrochlorothiazide NSAID = non-steroid anti-inflammatory drug. Source Author s estimates based on Verispan VONA, www.drugtopics.com/drugtopics/data/articlestandard/drugtopics/092007/407652/article.pdf. ... 

CGRP calcitonin gene-related peptide GABA y-aminobutyric acid 5-HT serotonin, 5-hydroxytryptamine IHS International Headache Society MAOIs monoamine oxidase inhibitors NSAIDs nonsteroidal anti-inflammatory drugs SSRI selective serotonin reuptake inhibitor TCA tricyclic antidepressant... 

NINCDS National Institute of Neurological and Communicative Disorders and Stroke NMDA N-methyl-D-aspartate NSAID nonsteroidal anti-inflammatory drug SSRI Selective serotonin reuptake inhibitor... 

A potentially dangerous interaction may occur between fluvoxamine and warfarin. There is a 65% increase in plasma warfarin concentration and a significant prolongation of prothrombin time. The selective serotonin reuptake inhibitors (SSRIs) increase the risk of upper gastrointestinal bleeding, and this effect is potentiated by the concurrent use of non-steroidal anti-inflammatory drugs (NSAIDs) or low-dose aspirin. There are anecdotal reports of bleeding disorder with the concomitant use of nicoumalone (a coumarin derivate), ibuprofen, and warfarin. 

NSAID, Nonsteroid anti-inflammatory drug SNRI, Selective serotonin and nonadrenaline reuptake inhibitor SSRI, Selective serotonin reuptake inhibitor... 

De Jong JCF, van den Berg PB, Tobi H, de Jong-van denBergLTW. Combined use of SSRIs and NSAIDs increases the risk of gastrointestinal adverse effects. Br J Clin Pharmacol (2003)55, 591-5. 

Serotonin release by platelets plays an important role in hemostasis. Psychotropic drugs that interfere with serotonin reuptake may increase the occurrence of upper gastrointestinal bleeding with concurrent use of an NSAID or aspirin. Altered anticoagulant effects have been reported when either SSRIs or SNRIs are co-administered with warfarin. Hemostasis in warfarin therapy should be carefully monitored whenever duloxetine is initiated or discontinued. 

NSAIDs nonsteroidal anti-inflammatory drugs, SSRI selective serotonin reuptake inhibitors, TCA tricyclic antidepressants Wang et al. (2014)... 

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