Novel Systems for New Chemistry Exploration

The success of the pharmaceutical industry depends largely on the synthesis and screening of novel chemical entities and their ability to optimize selected leads into marketable drugs. In a market where development costs are exceptionally high, the ability to shorten optimization times would be desirable to reduce this cost. Furthermore, new technology that would enable a cost-effective upward step-change in the number of lead candidates that could be prepared would provide an obvious competitive advantage, as this would potentially enable the discovery of a better lead with enhanced therapeutic properties, with reduced side effects. 

So how can a chemist make more compounds for evaluation Clearly the pharmaceutical industry has invested heavily in automation however, one of the slowest steps is still the synthesis, purification and isolation of potential drug candidates. Several pharmaceutical companies have acknowledged that new technology, such as microreactors, offer many fundamental and practical advantages of relevance to automated high throughput synthesis and product purification. 

Micro Instrumentation for High Throu put Experimentation and Process Intensification - a Tool for PAT Edited by M. V. Koch, K. M. VandenBussche and R. W. Chrisman Copyright 2007 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 978-3-527-31425-6 

For EOF to be achieved, polar solvent types must be used. The EOF fluid velocity 

Solvent Dielectric constant Viscosity (cP) Polarity index (P) Flow rate ( jL min ) 

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In addition to the more traditional applications, new applications of these versatile materials arc now being explored by an increasing number of research groups. These applications often utilize the unique spatial structuring of the zeolite channel system for novel concepts such as the stabilization of nanoscale forms of matter, size-selective chemical sensing, or separation of reaction spaces in electron transfer processes, to name just a few.[6,7] Furthermore, a number of novel applications depends not only on the control of pore structure and intrazeolite chemistry, but also on the ability to control the external morphology, for example in thin membranes for separations or in the design of sensor... 

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