19-Nortestosterone Nandrolone decanoate

Chemical Name 170-hydroxyestr-4-en-3-one 3-phenylpropionate Common Name 19-nortestosterone (3-phenylpropionate Structural Formula See Nandrolone Decanoate for the steroid structure Chemical Abstracts Registry No. 62-90-8 434-22-0 (Base)... 

Anabolic activities of testosterone, such as increases in amino acid incorporation into protein and in RNA polymerase activity, have been demonstrated in skeletal muscle. Apart from the direct anabolic effects in specific tissue, androgens antagonize the protein catabolic action of glucocorticoids. The androgen compounds with the greatest ratio of protein anabolic effects to virilizing effects are the 19-nortestosterone derivatives. Compounds that are used clinically (Table 63.3) include nandrolone phenpropionate (Durabolin), nandrolone decanoate... 

Nandrolone phenpropionate and nandrolone decanoate are esters of 19-nortestosterone, as shown in Figure 45.10, that when administered IM, slow in vivo hydrolysis of the ester occurs releasing free 19-nortestosterone over a prolonged period. Nandrolone deoanoate is the longer-acting ester intended for deep IM injeotion, preferably into the gluteal muscle, in the treatment of anemia assooiated with renal insuffioienoy. Nandrolone phenpropionate has a shorter duration of action than the deoanoate and is used in the treatment of metastatio breast cancer in women. 

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