19-Nortestosterone 17-Decanoate

Then the solution is dried on sodium sulfate, filtered, and evaporated to dryness. The residue, 1.63 grams is dissolved in hexane, this solution is filtered over 30 grams of neutral aluminum oxide, and evaporated to dryness. On paper chromatographic investigation it turned out that the obtained 19-nortestosterone 17-decanoate which at room temperature is an oil consists of a single compound, according to U.S. Patent 2,998,423. 

Therapeutic Function Anabolic Chemical Name 17 -[(1-oxodecvl)oxy] estr-4-en-3-one Common Name 19-nortestosterone decanoate norandrostenolone decanoate Structural Formula ... 

Common Name 19-nortestosterone decanoate norandrostenolone decanoate... 

Chemical Name 170-hydroxyestr-4-en-3-one 3-phenylpropionate Common Name 19-nortestosterone (3-phenylpropionate Structural Formula See Nandrolone Decanoate for the steroid structure Chemical Abstracts Registry No. 62-90-8 434-22-0 (Base)... 

Anabolic activities of testosterone, such as increases in amino acid incorporation into protein and in RNA polymerase activity, have been demonstrated in skeletal muscle. Apart from the direct anabolic effects in specific tissue, androgens antagonize the protein catabolic action of glucocorticoids. The androgen compounds with the greatest ratio of protein anabolic effects to virilizing effects are the 19-nortestosterone derivatives. Compounds that are used clinically (Table 63.3) include nandrolone phenpropionate (Durabolin), nandrolone decanoate... 

Total synthetic studies at Roussel-UCLAF produced a large number of compounds having this type of extended unsaturation. A ,A"-Nortes-tosterone 17-acetate (N-103), A, A -nortestosterone 17/3-methoxymethyl ether (N-104), A ,A -nortestosterone 17/3-decanoate (N-105), A A -nortestosterone 17-carbobenzoxy-ate (N-106), A ,A"-17a-methyl-... 

Nortestosterone cyclopentylpropionate has a myotrophic action approximately twice that of testosterone propionate but only about 20% of the androgenic properties of testosterone propionate [65]. In addition, 19-nortestosterone cyclohexylpropionate [247], 19-nortestosterone n-decanoate [148,248], 19-nortestosterone adamantoate [147], 19-nortestosterone 17/S-p-hexoxyphenyl propionate [249], 19-nortestosterone 17/3-hemisuccinate (sodium salt), and 19-nortestosterone propionate are in clinical use. 

Kim et al. [55] developed an LC-MS-MS method, based on positive-ion APCI mode and selected-reaction monitoring (SRM), for the doping analysis of 19-nortestosterone and three of its esters in plasma of race horses. The limits of quantification are 0.16, 0.1, 2.0, and 5.0 ng/ml for 19-nortestosterone, and its phenylpropionate, decanoate, and cyclopentanepropionate ester, respectively, using 2 ml of plasma. The method enabled detection of 19-nortestosterone np to 23 days... 

Nandrolone phenpropionate and nandrolone decanoate are esters of 19-nortestosterone, as shown in Figure 45.10, that when administered IM, slow in vivo hydrolysis of the ester occurs releasing free 19-nortestosterone over a prolonged period. Nandrolone deoanoate is the longer-acting ester intended for deep IM injeotion, preferably into the gluteal muscle, in the treatment of anemia assooiated with renal insuffioienoy. Nandrolone phenpropionate has a shorter duration of action than the deoanoate and is used in the treatment of metastatio breast cancer in women. 

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