Nonsteroidal antiinflammatory drugs acetaminophen

An individualized approach to treatment is necessary (Fig. 2-1). For mild or moderate pain, topical analgesics or acetaminophen can be used. If these measures fail or if there is inflammation, nonsteroidal antiinflammatory drugs (NSAIDs) may be useful. Appropriate nondrug therapies should be continued when drug therapy is initiated. 

General supportive measures, including acetaminophen as an antipyretic (aspirin or other nonsteroidal antiinflammatory drugs may displace bound thyroid hormone), fluid and electrolyte replacement, sedatives, digoxin, antiarrhythmics, insulin, and antibiotics should be given as indicated. Plasmapheresis and peritoneal dialysis have been used to remove excess hormone in patients not responding to more conservative measures. 

Pain management should begin with nonnarcotic analgesics such as acetaminophen or a nonsteroidal antiinflammatory drug administered on a scheduled basis before meals to prevent postprandial exacerbation of... 

Mild to moderate pain should be treated with nonsteroidal antiinflammatory drugs or acetaminophen. 

Aspirin or acetaminophen with butalbital, caffeine Isometheptene 65 mg/dichloralphenazone 100 mg/acetaminophen 325 mg (Midrin) Nonsteroidal antiinflammatory drugs... 

There are two major classes of pain medications, nonopioids and opioids. The nonopioids used to treat mild pain include agents such as acetaminophen, both steroid and nonsteroidal antiinflammatory drugs (NSAIDs), and acetylsalicylic acid. Anticonvulsants suppress neuronal firing and are also helpful in neuropathic pain. Antiinflammatory agents (e.g., NSAIDs or corticosteroids) may be particularly helpful when bony involvement occurs and are often used for low-intensity pain. Steroids decrease inflammatory edema and are useful in cases of nerve and spinal cord compression, lymphedema, visceral pain caused by organ enlargement, and bone pain. Finally, short-term corticosteroid therapy may also produce euphoria (thus ameliorating less severe depressions) as well as reverse anorexia. 

Dozens of combination products are available only a few of the most commonly prescribed ones are listed here. Codeine combination products available in several strengths are usually denoted No. 2 (15 mg codeine), No. 3 (30 mg codeine), and No. 4 (60 mg codeine). Prescribes should be aware of the possible danger of renal damage with acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs contained in these analgesic combinations. 

PernegerTV, Whelton PK, Klag MJ. Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med 1994 331 1675-1679. 

NSAIDs (nonsteroidal antiinflammatory drugs) Isolated cases of adverse neurological side effects have been seen with naproxen or phenylbutazone given with misoprostol. Misoprostol also increases the abdominal pain and other side effects of diclofenac and indometacin (indomethacin). Paracetamol (acetaminophen) intensifies pain if given with mifepristone and sulprostone used to induce abortion. 

Aspirin, acetaminophen, the other nonnarcotic nonsteroidal antiinflammatory drugs (NSAIDs) used to treat pain and inflammation, and the drugs used for hyperuricemia and gout. 

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