Non-animal stabilized

Altman RD, Akermark C, Beaulieu AD, Schnitzer T. Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee. Osteoarthritis Cartilage 2004 12 642-649. 

Delorenzi C, Weinberg M, Solish N, Swift A. A multicenter study of the efficacy and safety of subcutaneous non-animal stabilized hyaluronic acid in aesthetic facial contouring interim report. Dermatol Surg 2006 32 205-211. 

Verpaele A, Strand A. Restylane SubQ, a non-animal stabilized hyaluronic acid gel for soft tissue augmentation of the mid- and lower face. Aesthet Surg 2006 26 S10-S17. 

Uses In addition to its use as a cosmetic filler, non-animal-stabilized hyaluronic add/ dextranomer gel has been used to treat vesi-coureteric refiux in children by endoscopic injection [10 ]. In 166 patients, mean age 4.2 (range 0-16) years reflux was resolved in 82% after one treatment and in 90% after a second or third treatment there were no adverse reactions. In a similar study in 71 patients the response rate at 12 months after the last endoscopic treatment was 62% there were two mild adverse events and one moderate laboratory change potentially relating to the gel [11 ]. 

Skin In 22 women and 8 men (age range 45-55 years) in whom nasolabial creases were corrected by injecting the non-animal stabilized hyaluronic acid fillers Restylane and Perlane, minor adverse reactions after injection included erythema at the puncture site, needle marks, and bruising [12. ... 

CAS 153065-40-8 68424-59-9 EINECS/ELINCS 293-165-5 293-515-7 Uses Primary w/o emulsifier, sec. o/w emulsifier/stabilizer, moisturizer, humectant in creams, lotions, lip care, ointments, phannaceulicals Features Rec. where non-animal derived ingreds. are important exc. water absorp. 

The test animals should be maintained in the testing facility before the administration starts. In the case of rodents, a one week acclimatization period is necessary. In the case of the use of non-rodents at least 4 weeks are necessary. For animals imported from other (tropic or sub-tropic) countries, e.g. monkeys, longer periods are necessary for stabilization and required by veterinary regulations (acclimatization and quarantine). The comparison of data from pre-tests with results after certain periods of exposure can provide information with regard to time of development of symptoms. 

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